Mouse Anti-Human EGFR Monoclonal Antibody


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Mouse Anti-Human EGFR Monoclonal Antibody

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Cat. No. : CAB-11472MH
Product Overview : Anti-human EGFR mAb,is derived from hybridization of mouse F0 myeloma cells with spleen cellsfrom BALB/c mice immunized with a recombinant human EGFR protein.
Antigen Description : Epidermal growthfactor receptor (EGFR) is a 170 kDa membrane protein first identified as abinding partner of EGF. Also, EGFR phosphorylated itself(autophosphorylation) in response to EGF treatment. The overexpression of EGFRin various epithelial tumors was widely reported and it has beensubstantiated that deregulation of EGFR itself and its signaling pathways animportant role in human cancers.
Immunogen : Recombinant humanEGFR (424-605aa) purified from E. coli.
Host : Mouse
Isotype : MouseIgG2b heavy chain and κ light chain.
Application : ELISA; WB;ICC
Clone : BU3I9
Description : EGFR isthe cell-surface receptor for members of the epidermal growth factor family(EGF-family) of extracellular protein ligands.
Concentration : 1 mg/ml
Form : Liquid.In Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
Usage : Theantibody has been tested by ELISA, Western blot analysis to assurespecificity and reactivity. Since application varies, however, eachinvestigation should be titrated by the reagent to obtain optimal results.Recommended dilution range for Western blot analysis is 1:250.Immunofluorescence is 1:250. Recommended starting dilution is 1:250.
Storage : Can bestored at +4°C. For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
Gene Name : EGFR epidermalgrowth factor receptor [ Homo sapiens ]
Official Symbol : EGFR
Synonyms : EGFR;epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61;proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cellproliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1;avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; EC;OTTHUMP00000159661; OTTHUMP00000159662; OTTHUMP00000159663;OTTHUMP00000209210; OTTHUMP00000209211; EC 2.7.10; epidermal growth factorreceptor (avian erythroblastic leukemia viral (v-erb-b); erythroblasticleukemia viral (v-erb-b) oncogene homolog; leukemia viral (v-erb-b) oncogenehomolog
Gene ID : 1956
mRNA Refseq : NM_005228
Protein Refseq : NP_005219
MIM : 131550
UniProt ID : P00533
Chromosome Location : 7p12
Pathway : Adherens junction; Alpha6-Beta4Integrin Signaling Pat; Androgen Receptor Signaling Pathway; Arf6 signalingevents; Axon guidance; Bladder cancer; Calcium signaling pathway;Cytokine-cytokine receptor interaction; Delta-Notch Signaling Pathway;Developmental Biology; Direct p53 effectors; Dorso-ventral axis formation;E-cadherin signaling in keratinocytes; EGF receptor (ErbB1) signalingpathway; EGFR downregulation
Function : ATP binding; MAP/ERK kinase kinaseactivity; actin filament binding; double-stranded DNA binding; enzymebinding; epidermal growth factor-activated receptor activity; identicalprotein binding; contributes to nitric-oxide synthase regulator activity;nucleotide binding; protein binding; protein heterodimerization activity;protein phosphatase binding; protein tyrosine kinase activity; receptoractivity; signal transducer activity

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