"Bmp4" Related Products

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Recombinant Murine BMP4

Cat. No.: Bmp4-578TM
Product Overview: Recombinant Murine BMP4 encoding murine BMP4 was expressedin E.coli.
Description: Bone morphogenetic proteins (BMPs) constitute a subfamilywithin the TGF-β superfamily of structurally related signaling proteins.Members of this superfamily are widely distributed throughout the body andare involved in diverse physiological processes during both pre- andpostnatal life. Like BMP-7, BMP-4 is involved in the development and maintenanceof bone and cartilage. Reduced expression of BMP-4 is associated with anumber of bone diseases, including the heritable disorder FibrodysplasiaOssificans Progressiva. PeproTech's E.coli derived murine BMP-4 is a fullyactive homodimeric protein consisting of two 106 amino acid subunits whichcorrespond to amino acids 303-408 of the full length BMP-4 precursor.
Source: E.coli
Biological Activity: Determined by its ability to induce alkaline phosphataseproduction by ATDC-5 cells. The expected ED50 for this effect is 5-15 ng/ml.
AA Sequence: KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNSTNHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCRKKNK NCRRHSLYVDFSDVGWNDWI VAPPGYQAFY CHGDCPFPLA DHLNSTNHAI VQTLVNSVNS SIPKACCVPT ELSAISMLYLDEYDKVVLKN YQEMVVEGCG CR
Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.
Gene Name: Bmp4 bonemorphogenetic protein4 [ Mus musculus ]
Official Symbol: Bmp4
Synonyms: Bmp4; bonemorphogenetic protein 4; Bmp-4; Bmp2b; Bmp2b1;Bmp2b-1; BMP-2B; bonemorphogenetic protein 2B
Gene ID: 12159
mRNA Refseq: NM_007554
Protein Refseq: NP_031580
UniProt ID: Q3ULR1
Chromosome Location: 14 C1
Pathway: Adipogenesis; Basalcell carcinoma; ESCPluripotency Pathways; Hedgehog signaling pathway;Pathways in cancer; PluriNetWork;TGF Beta Signaling Pathway; TGF-betasignaling pathway
Function: BMP receptor binding; chemoattractant activity;cytokine activity; growth factor activity; heparinbinding; protein binding;protein homodimerization activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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