Recombinant Human CLPP, His-tagged

• Cat.No.: CLPP-3538H
• Product Overview: Recombinant humanCLPP protein was expressed in E. coli and purified by using conventionalchromatography techniques.

Specification

• Species: Human
• Source: Human
• Tag: His
• Description: CLPP belongs to thepeptidase family S14. CLPP cleaves peptides in various proteins in a processthat requires ATP hydrolysis. CLPP, the catalytic core of the Clp proteolyticcomplex, is widely involved in many cellular processes via the regulation ofintracellular protein quality. CLPP may be responsible for a fairly generaland central housekeeping function rather than for the degradation of specificsubstrates.
• Application: SDS-PAGE
• Form: Liquid. In 20mM Tris-HClbuffer (pH 8.0) containing 2mM DTT, 20% glycerol, 200mM NaCl.
• Molecular Weight: 24.2 kDa (222aa),confirmed by MALDI-TOF
• Purity: > 90% by SDS-PAGE
• Concentration: 0.5 mg/ml(determined by Bradford assay)
• Sequences of aminoacids: MPLIPIVVEQTGRGERAYDI YSRLLRERIV CVMGPIDDSV ASLVIAQLLF LQSESNKKPI HMYINSPGGV VTAGLAIYDTMQYILNPICT WCVGQAASMG SLLLAAGTPG MRHSLPNSRI MIHQPSGGAR GQATDIAIQA EEIMKLKKQLYNIYAKHTKQ SLQVIESAME RDRYMSPMEA QEFGILDKVL VHPPQDGEDE PTLVQKEPVE AAPAAEPVPAST
• Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• OfficialSymbol: CLPP

Gene Information

• Gene Name: CLPP ClpP caseinolyticpeptidase, ATP-dependent, proteolytic subunit homolog (E. coli) [ Homosapiens ]
• Synonyms: CLPP; ClpPcaseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli);putative ATP-dependent Clp protease proteolytic;subunit, mitochondrial; endopeptidase Clp; ATP-dependent protease ClpAP,proteolytic subunit, human; ClpP caseinolytic peptidase ATP-dependent,proteolytic subunit; ClpP caseinolytic protease, ATP-dependent, proteolyticsubunit homolog; EC 3.4.21.92; putative ATP-dependent Clp proteaseproteolytic subunit, mitochondrial
• Gene ID: 8192
• mRNA Refseq: NM_006012
• Protein Refseq: NP_006003
• MIM: 601119
• UniProt ID: Q16740
• Chromosome Location: 19p13.3
• Function: ATP binding; nucleotidebinding; peptidase activity; protein binding; serine-type endopeptidaseactivity