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Recombinant Human CLPP, His-tagged

Cat.No. : CLPP-3538H
Product Overview : Recombinant humanCLPP protein was expressed in E. coli and purified by using conventionalchromatography techniques.
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Cat. No. : CLPP-3538H
Description : CLPP belongs to thepeptidase family S14. CLPP cleaves peptides in various proteins in a processthat requires ATP hydrolysis. CLPP, the catalytic core of the Clp proteolyticcomplex, is widely involved in many cellular processes via the regulation ofintracellular protein quality. CLPP may be responsible for a fairly generaland central housekeeping function rather than for the degradation of specificsubstrates.
Application : SDS-PAGE
Form : Liquid. In 20mM Tris-HClbuffer (pH 8.0) containing 2mM DTT, 20% glycerol, 200mM NaCl.
Molecular Weight : 24.2 kDa (222aa),confirmed by MALDI-TOF
Purity : > 90% by SDS-PAGE
Concentration : 0.5 mg/ml(determined by Bradford assay)
Sequences of aminoacids : MPLIPIVVEQTGRGERAYDI YSRLLRERIV CVMGPIDDSV ASLVIAQLLF LQSESNKKPI HMYINSPGGV VTAGLAIYDTMQYILNPICT WCVGQAASMG SLLLAAGTPG MRHSLPNSRI MIHQPSGGAR GQATDIAIQA EEIMKLKKQLYNIYAKHTKQ SLQVIESAME RDRYMSPMEA QEFGILDKVL VHPPQDGEDE PTLVQKEPVE AAPAAEPVPAST
Storage : Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
OfficialSymbol : CLPP
Gene Name : CLPP ClpP caseinolyticpeptidase, ATP-dependent, proteolytic subunit homolog (E. coli) [ Homosapiens ]
Synonyms : CLPP; ClpPcaseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli);putative ATP-dependent Clp protease proteolytic;subunit, mitochondrial; endopeptidase Clp; ATP-dependent protease ClpAP,proteolytic subunit, human; ClpP caseinolytic peptidase ATP-dependent,proteolytic subunit; ClpP caseinolytic protease, ATP-dependent, proteolyticsubunit homolog; EC 3.4.21.92; putative ATP-dependent Clp proteaseproteolytic subunit, mitochondrial
Gene ID : 8192
mRNA Refseq : NM_006012
Protein Refseq : NP_006003
MIM : 601119
UniProt ID : Q16740
Chromosome Location : 19p13.3
Function : ATP binding; nucleotidebinding; peptidase activity; protein binding; serine-type endopeptidaseactivity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there any potential therapeutic approaches targeting CLPP? 08/06/2022

Targeting CLPP therapeutically could offer potential in diseases related to mitochondrial dysfunction and aging.

How is the activity of CLPP regulated within the cell? 08/05/2020

CLPP activity is tightly regulated to ensure balanced protein turnover in mitochondria.

In which conditions is CLPP dysregulation observed, and what are its implications? 07/01/2020

Dysregulation of CLPP is linked to various diseases, including mitochondrial disorders.

How does CLPP contribute to mitochondrial protein quality control? 12/21/2019

It helps in degrading misfolded or damaged proteins, maintaining mitochondrial function.

What role does CLPP play in mitochondrial function and health? 07/27/2018

Proper functioning of CLPP is vital for mitochondrial health and energy production.

What is the significance of CLPP in aging and longevity? 07/26/2018

CLPP levels and activity are associated with aging, influencing cellular senescence and longevity.

What is the main function of CLPP in cellular processes? 05/13/2018

CLPP plays a crucial role in mitochondrial protein degradation and quality control.

Customer Reviews (3)

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Reviews
05/03/2022

    Very high purity level.

    11/15/2019

      Worked excellently in experiments.

      08/05/2018

        Product was well packaged.

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