"CPE" Related Products

Recombinant mouse Carboxypeptidase E,His-tagged

Cat. No.: CPE-2891M
Product Overview: Recombinant MouseCarboxypeptidase E (rmCPE), Met1-Phe476 fused with 6×his tag at C-terminuswas expressed in human HEK293 cells
Description: CarboxypeptidaseE (CPE), also known as Carboxypeptidase H or enkephalin convertase.Carboxypeptidase E cleaves C-terminal amino acid residues and is involved inneuropeptide processing. It is a peripheral membrane protein. CPEspecifically binds regulated secretory pathway proteins, includingprohormones, but not constitutively secreted proteins. Carboxypeptidase Eappears to have several functions. The active form of carboxypeptidase E wasshown to be in secretory vesicles, where it acts as an exopeptidase toactivate neuropeptides, It does that by cleaving off basic C-terminal aminoacids, producing the active form of the peptide. Products of carboxypeptidaseE include insulin, enkephalin, and most other neuroendocrine peptides.It hasalso been proposed that membrane-associated carboxypeptidase E acts as asorting signal for regulated secretory proteins in the trans-Golgi network ofthe pituitary and in secretory granules; regulated secretory proteins aremostly hormones and neuropeptides. Mice with mutant carboxypeptidase E Cpe,display endocrine disorders like obesity and infertility.
Source: Human HEK293 cells
Formulation: Bulk protein in a0.22 μm filtered solution of PBS, pH 7.4 and delivered as liquid formulationor lyophilized powder.Normally 5-8% trehalose and mannitol are added asprotectants before lyophilization.
Predicted N-terminal: Gln28
Species: Mouse
Purify: >95% asdetermined by SDS-PAGE. All lots are greater than 95% pure.
Storage: Store at -20℃ in lyophilizedstate after receipt. For long term storage, upon reconstitution rmCPE shouldbe aliquot and store at -20℃ or -80℃. Avoid repeated freeze-thaw cycles.
Gene Name: Cpe carboxypeptidase E [Mus musculus ]
Official Symbol: Cpe
Synonyms: Cpe;carboxypeptidase E; carboxypeptidase E; carboxypeptidase E; carboxypeptidaseH; enkephalin convertase; prohormone-processing carboxypeptidase
Gene ID: 12876
mRNA Refseq: NM_013494
Protein Refseq: NP_038522
MIM: 31395
UniProt ID: Q00493
Chromosome Location: 8 B3.1
Pathway: Diabetes pathways; Disease; InsulinSynthesis and Processing; Type I diabetes mellitus; Type I diabetes mellitus
Function: carboxypeptidase activity; celladhesion molecule binding; cobalt ion binding; hydrolase activity; metal ionbinding; metallocarboxypeptidase activity; metallopeptidase activity;neurexin family protein binding; peptidase activity; zinc ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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