Native Human Haptoglobin


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Native Human Haptoglobin

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Cat.No. : HP-4387H
Product Overview : Human HP produced from pooled human plasma corresponding to the Mw of isotypes of HP at 86kD and 200kD.
Description : HP is a glycoprotein which is synthesized in the liver and circulates in the blood. HP is produced typically by hepatocytes but also by other tissues: e.g. skin, lung, and kidney. It is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury, and iron loss following hemolysis. The HP-hemoglobin complex is subsequently removed by the reticuloendothelial system (generally the spleen). As the reticuloendothelial system removes the HP-hemoglobin complex from the body, HP levels are reduced in hemolytic anaemias. In the course of binding hemoglobin, HP sequesters the iron inside hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis.
Source : Pooled human plasma
Species : Human
Form : Lyophilized from 0.02M NH4HCO3. May contain traces of buffer salts.
Purity : Greater than 96.0%.
Storage : Human HP although stable at room temperature for 3 weeks, should be stored between 2-8°C.
Gene Name : HP haptoglobin [ Homo sapiens ]
Official Symbol : HP
Synonyms : HP; haptoglobin; zonulin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide; BP; HPA1S; HP2ALPHA2; MGC111141;
Gene ID : 3240
mRNA Refseq : NM_001126102
Protein Refseq : NP_001119574
MIM : 140100
UniProt ID : P00738
Chromosome Location : 16q22.2
Pathway : amb2 Integrin signaling, organism-specific biosystem;
Function : catalytic activity; hemoglobin binding; serine-type endopeptidase activity;

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