Bovine Myelin basic protein, Biotin-Conjugated MBP-6949B

Bovine Myelin basic protein, Biotin-Conjugated

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Bovine Myelin basic protein, Biotin-Conjugated

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Cat. No. : MBP-6949B
Product Overview : Bovine Myelinbasic protein, biotin-conjugated, was highly Purifiedfrom bovine central nervous system tissue by method of Määttä et al.
Description : MBP is a peripheralmembrane protein, and its interaction with lipids is generally believed to becritical for the formation and stability of the multilamellar myelin sheath.It has been identified as a Ca2+-calmodulin regulated agent foractin polymerization, tropomyosin and actomyosin function, tubulinstabilization, and clathrin assembley. MBP is generally considered to be theantigen responsible for autoimmunity in multiple sclerosis (MS) and it hasthe capability to induce experimental allergic encephalomyelitis (EAE). MBPis also an endogenous inhibitor of the high-affinity cannabinoid binding sitein the brain and a substrate for numerous protein kinases (MAPK,serine/threonine kinase, protein kinase C). MBP is also suggested to beinvolved in intracellular signalling and as cytoskeletal components.
Source : bovine central nervous system tissue
Purity : ≥95% (SDS-PAGE; immunoblot)
Formulation : Lyophilized. Essentially salt-free.
Reconstitution : Reconstitute with distilled water.
Application : Substratefor various kinases including MAPK, PKA, calmodulin-dependent protein kinase,PKC and phosphorylase kinase. Raf1, MEK, and MEKK can also use MBP as asubstrate. The biotinyl moiety allow this substrate to be used in conjunctionwith a streptavidin membrane in kinase assays.
Storage : Stablefor at least 1 year when stored at +4°C. Reconstituted protein is stable forat least 6 months at -20°C and for at least 24 hours at +37°C in aqueoussolution.
Renderingof MBP from PDB 1BX2 :

Gene Name : MBP myelin basic protein [ Bostaurus ]
Official Symbol : MBP
Synonyms : MBP;myelin basic protein; myelin A1 protein; microtubule-stabilizing protein; 20kDa microtubule-stabilizing protein
Gene ID : 618684
mRNA Refseq : NM_001206674
Protein Refseq : NP_001193603
Chromosome Location : 24q11-q13.2
Function : structuralconstituent of myelin sheath

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