"SNTN" Related Products

Recombinant Human Sentan, Cilia Apical Structure Protein, His-tagged

Cat. No. : SNTN-3521H
Product Overview : Recombinant human SNTN protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography (1-147aa).
Description : SNTN, also known as sentan, belongs to the S-100 family. SNTN is shown to localize exclusively to the bridging structure between the cell membrane and peripheral singlet microtubules, which specifically exists in the narrowed distal portion of cilia. Exogenously expressed sentan showed affinity for the membrane protrusions, and a protein-lipid binding assay revealed that sentan bound to phosphatidylserine. These findings suggest that sentan is the first molecular component of the ciliary tip to bridge the cell membrane and peripheral singlet microtubules, making the distal portion of the cilia narrow and stiff to allow for better airway clearance or ovum transport.
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 50% glycerol, 0.15M NaCl, 1mM DTT
Molecular Weight : 18.6 kDa (167aa), confirmed by MALDI-TOF
Purity : >90% by SDS - PAGE
Concentration : 0.5 mg/ml (determined by Bradfordassay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MGGCMHSTQD KSLHLEGDPN PSAAPTSTCA PRKMPKRISI SKQLASVKAL RKCSDLEKAI ATTALIFRNS SDSDGKLEKA IAKDLLQTQF RNFAEGQETK PKYREILSEL DEHTENKLDF EDFMILLLSI TVMSDLLQNI RNVKIMK
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
Gene Name : SNTN sentan, cilia apical structure protein [ Homo sapiens ]
Synonyms : SNTN; S100AL; S100A1L; FLJ44379; sentan; sentan, cilia apical structure protein; OTTHUMP00000213412; OTTHUMP00000213414; S100A-like protein
Gene ID : 132203
mRNA Refseq : NM_001080537
Protein Refseq : NP_001074006
UniProt ID : A6NMZ2
Chromosome Location : 3p14.2
Function : calcium ion binding

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