Rabbit Anti-Human ADAM Metallopeptidase Domain 12 Polyclonal Antibody

• Cat.No.: CPBT-676RH
• Product Overview: Rabbit Anti-Human ADAM metallopeptidase domain 12 Polyclonal Antibody.

Specification

• Cat. No.: CPBT-676RH
• Antigen Dscription: ADAM12, also named as MLTN and Meltrin-alpha, is involved in skeletal muscle regeneration, specifically at the onset of cell fusion. It is also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. ADAM12 is expressed in human malignant tumors. It is involved in the regulation of growth factor activities and integrin functions, leading to promotion of cell growth and invasion, although the precise mechanisms of these are not clear at the present time.(PMID:17355265) ADAM12's ability to degrade extracellular matrix components likely allows it to detach cancer cells from the basement membrane and assist them on their route to metastasis. But the protein's role not just as a biomarker of breast cancer but as a gateway to cancer cell migration is only now being understood.
• Host Animal: Rabbit
• Species Reactivity: Human
• Immunogen: Human ADAM12 gst fusion protein
• Isotype: IgG
• Purification: Antigen Affinity purified
• Caculated Molecular Weight: 100kd
• Observed Molecular Weight: 97kd,68kd
• Applications: ELISA, WB, IHC, IF
• Storage: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 oC, Avoid freeze / thaw cycles.
• Officialsymbol: ADAM12

Gene Information

• Gene Name: ADAM12 ADAM metallopeptidase domain 12 [ Homo sapiens ]
• Synonyms: ADAM12; ADAM metallopeptidase domain 12; MCMP; MCMPMltna; MLTN; MLTNA; A Disintegrin and Metalloprotease Domain 12 S isoform; ADAM12 precursor (EC 3.4.24); Meltrin alpha; ADAM12 ADAM metallopeptidase domain 12; OTTHUMP00000020727; OTTHUMP00000046766; a disintegrin and metalloproteinase domain 12 (meltrin alpha); EC 3.4.24.; A disintegrin and metalloproteinase domain 12
• Gene ID: 8038
• mRNA Refseq: NM_003474
• Protein Refseq: NP_003465
• MIM: 602714
• UniProt ID: O43184
• Chromosome Location: 10q26.3
• Pathway: Signaling by EGFR
• Function: SH3 domain binding; metal ion binding ; metalloendopeptidase activity; peptidase activity; protein binding; zinc ion binding