Recombinant Human ABCB1, GST-tagged
Cat.No. : | ABCB1-2548H |
Product Overview : | The protein was expressed as GST-tagged fusion protein by E. coli and Purified by GSH-sepharose. |
- Specification
- Gene Information
- Related Products
Cat. No. : | ABCB1-2548H |
Description : | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. |
Source : | E. coli |
Antigen PeptideRegion : | 624-708aa |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Storage : | The protein is stored in PBS buffer at -20°C. Repeated freeze-thaw cycles should be avoided. |
Gene Name : | ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 [ Homo sapiens ] |
Official Symbol : | ABCB1 |
Synonyms : | ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; MGC163296; multidrug resistance protein 1; P-glycoprotein 1;colchicin sensitivity; doxorubicin resistance; EC 3.6.3.44 |
Gene ID : | 5243 |
mRNA Refseq : | NM_000927 |
Protein Refseq : | NP_000918 |
MIM : | 171050 |
UniProt ID : | P08183 |
Chromosome Location : | 7q21.12 |
Pathway : | ABC transporters; ABC-family proteins mediated transport; Bile secretion; Codeine and morphine metabolism; HIF-1-alpha transcription factor network; Nuclear receptors in lipid metabolism and toxicity; Transmembrane transport of small molecules |
Function : | ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; hydrolase activity; nucleotide binding; protein binding; transporter activity; xenobiotic-transporting ATPase activity |
Products Types
◆ Recombinant Protein | ||
ABCB1-9C | Recombinant Cynomolgus Monkey ABCB1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABCB1-235H | Recombinant Human ABCB1 Protein, DDK-tagged | +Inquiry |
ABCB1-2591H | Recombinant Human ABCB1 protein(381-660 aa), C-His-tagged | +Inquiry |
ABCB1-6R | Recombinant Rhesus Macaque ABCB1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABCB1-115H | Recombinant Human ABCB1 Protein, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket