Rabbit Monoclonal Antibody to Human Myelin Oligodendrocyte Glycoprotein

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Rabbit Monoclonal Antibody to Human Myelin Oligodendrocyte Glycoprotein

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Cat.No. : CAB11583RH
Product Overview : Rabbit Monoclonal Antibody to Human Myelin Oligodendrocyte Glycoprotein
Antigen Description : Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals.
Specificity : Human MOG. No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA.
Immunogen : Recombinant Human MOG Protein
Host : Rabbit
Isotype : Rabbit IgG
Species : Human
Clone : A014
Applications : Western blot; ELISA
Dilution : Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human MOG in WB.Direct ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human MOG. The detection limit for Human MOG is approximately 0.00975 ng/well.
Preparation : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Human MOG
Format : 0.2 μm filtered solution in PBS with 5% trehalose
Storage : This antibody can be stored at 2-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name : MOG myelin oligodendrocyte glycoprotein [ Homo sapiens ]
Official Symbol : MOG
Synonyms : MOG; myelin oligodendrocyte glycoprotein; myelin-oligodendrocyte glycoprotein; MOG Ig-AluB; MOG alpha-5; MOGIG2; NRCLP7; MGC26137;
Gene ID : 4340
mRNA Refseq : NM_001008228
Protein Refseq : NP_001008229
MIM : 159465
UniProt ID : Q16653
Chromosome Location : 6p22-p21.3

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