Recombinant Mouse CD33 Antigen, Fc-tagged
Cat.No. : | Cd33-6889M |
Product Overview : | A DNA sequence encoding the extracellular domain of mouse Cd33 ( Met 1 - Glu 240 ) was fused with the Fc region of human IgG1 at the C-terminus. It comprises 465 amino acids and has a calculated molecular mass of 51.6 kDa. |
- Specification
- Gene Information
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Description : | Mouse myeloid cell surface antigen Cd33 is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Cd33 contains 1 Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. |
Source : | Human Cells |
Species : | Mouse |
Tag : | Fc |
Predicted N Terminal : | Gln 17 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Molecular Mass : | The secreted recombinant mouse Cd33 / Fc is a disulfide-linked homodimer. The reduced monomer comprises 465 amino acids and has a calculated molecular mass of 51.6 kDa. As a result of glycosylation, the apparent molecular mass of rm CD33 / Fc monomer is approximately 55 - 60 kDa in SDS-PAGE under reducing conditions. |
Protein length : | 465aa |
Endotoxin : | 1.0 eu/μg of the protein as determined by the lal |
Purity : | >90 % as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 °C. |
Storage : | Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | Cd33 CD33 antigen [ Mus musculus ] |
Official Symbol : | Cd33 |
Synonyms : | CD33; CD33 antigen; myeloid cell surface antigen CD33; sialic acid-binding Ig-like lectin 3; gp67; Siglec-3; |
Gene ID : | 12489 |
mRNA Refseq : | NM_001111058 |
Protein Refseq : | NP_001104528 |
Pathway : | Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; |
Function : | sugar binding; |
Products Types
◆ Lysates | ||
CD33-978HCL | Recombinant Human CD33 cell lysate | +Inquiry |
CD33-1808MCL | Recombinant Mouse CD33 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionCertain polymorphisms in the CD33 gene can influence its expression on the cell surface, which might affect the efficacy of CD33-targeted therapies.
CD33 is a transmembrane receptor primarily expressed on cells of myeloid lineage and is involved in modulating cellular functions, including the regulation of cellular proliferation and differentiation.
CD33 is predominantly expressed on myeloid cells, especially on immature myeloid cells. Its expression decreases as these cells differentiate and is typically low or absent on lymphoid cells.
CD33 has been targeted for therapeutic antibodies in AML. An example is gemtuzumab ozogamicin, which targets CD33 and delivers a cytotoxic agent specifically to leukemia cells expressing CD33.
While the exact signaling pathways of CD33 are still under investigation, it is believed that CD33 signaling can influence the differentiation and function of myeloid cells, potentially playing a role in immune regulation.
CD33 is commonly expressed on the surface of AML blasts, making it a potential target for therapeutic interventions in AML.
The specific ligands for CD33 are not fully characterized, but it is believed to play a role in cell-cell interactions within the immune system.
Customer Reviews (3)
Write a reviewQuick dissolution, easy use.
Excellent solubility, no aggregates.
High concentration, very effective.
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