Recombinant Human CALM1

• Cat.No.: CALM1-90H

Specification

• Cat. No.: CALM1-90H
• Description: The human Calmodulin 1 full-lengthrecombinant protein was expressed in E. coli.
• Introduction: Calmodulin 1 is a member of calcium-modulated proteins, which is present in the cytosol and on membranes facing the cytosol, and has a high affinity for calcium. Calmodulin 1 has 4 calcium-binding domains and plays a role in cell growth, cell cycle, signal transduction, and the synthesis and release of neurotransmitters. Calmodulin can bind to the epidermal growth factor receptor at its cytosolic juxtamembrane region and this inhibits its tyrosine kinase activity. A number of other proteins including HSP70 have been shown to interact with Calmodulin 1 in a cell-phase-specific manner.
• AA Sequence: MADQLTEEQIAEFKEAFSLFDKDGD GTITTKELGTVMRSLGQNPTEAELQ DMINEVDADGNGTIDFPEFLTMMAR KMKDTDSEEEIREAFRVFDKDGNGY ISAAELRHVMTNLGEKLTDEEVDEM IREADIDGDGQVNYEEFVQMMTAK
• Source: E. coli
• Molecular weight: 16kDa
• Formulation: Liquid, in 20 mMTris, pH 7.5
• Stability: Store at 4°C for 1-2 weeks. For long term storage store at -20°C or -80°C. Aliquot to avoid repeated freezing and thawing.
• Purification: Conventional Chromatography
• Concentration: 1 mg/ml
• Purity: > 90% as determined by SDS-PAGE.
• SDS PAGE: Loading 3 ug protein in 15% SDS-PAGE

Gene Information

• Gene Name: CALM1 calmodulin 1 (phosphorylase kinase, delta) [ Homo sapiens ]
• Official Symbol: CALM1
• Synonyms: CALM1; calmodulin 1 (phosphorylase kinase, delta); CAMI; PHKD; DD132; CALML2; calmodulin 1; phosphorylase kinase, delta subunit; EC 2.7.11.19; CALMCAM; CAM1; CAM2; CAM3; CAMB; CAMC; CAMIII; CaM
• Gene ID: 801
• mRNA Refseq: NM_006888
• Protein Refseq: NP_008819
• MIM: 114180
• UniProt ID: P62158
• Chromosome Location: 14q24-q31
• Pathway: Alzheimer"s disease; Calcium signaling pathway; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term potentiation; Melanogenesis; Neurotrophin signaling pathway; Olfactory transduction; Phosphatidylinositol signaling system; Vascular smooth muscle contraction