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Recombinant Human IgG Fc Control Protein

Cat.No. : IgG-02H
Product Overview : Recombinant Human IgG Fc Control Protein was expressed in HEK293 Cells and purified using protein A-agarose.
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Cat. No. : IgG-02H
Description : Recombinatant fusion proteins consisting of the extracellular domain of immunoregulatory proteins and the constant (Fc) domain of immunoglobulin G (IgG) represent a growing class of human therapeutics. Chimeric protein of Human target protein and Human IgG-Fc domain can be purified using protein A chromatography.
Source : HEK293 Cells
Species : Human
Predicted MolecularMass : ~ 55 kDa
Formulation : 50µg of recombinant protein in 50µl of 1X PBS, 20%(v/v) glycerol. Frozen solution.
Concentration : 1 mg/mL
Purity : Greater than 90% by SDS-PAGE and Coomassie blue staining. Western blotting by primary antibody Mouse anti-Human IgG, clone HP6017, Fc and secondary antibody Goat anti-Mouse IgG, HRP conjugate
Storage : Best stored at -80°C for up to 6 months after date of receipt. Thawed aliquots should be used immediately, as repeated freeze/thaw cycles might result in loss of activity.
Background :
IntroductionImmunoglobulin G (IgG) is an antibody isotype. It is a protein complex composed of four peptide chains — two identical heavy chains and two identical light chains arranged in a Y-shape typical of antibody monomers. Each IgG has two antigen binding sites. Representing approximately 75% of serum immunoglobulins in humans, IgG is the most abundant antibody isotype found in the circulation. IgG molecules are synthesized and secreted by plasma B cells.
KeywordsIgG Fc; IgG Fc(Human); Recombinant Human IgG Fc
Publication :
The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity (2015)

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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