Recombinant Human NADH Dehydrogenase (ubiquinone) Fe-S Protein 4, 18kDa (NADH-coenzyme Q reductase)

• Cat.No.: NDUFS4-2509H
• Product Overview: Recombinant human NDUFS4 protein was expressed in E. coli and purified by using conventional chromatography. MW: 15.5 kDa.

Specification

• Description: NDUFS4 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone.
• Source: E. coli
• Species: Human
• Tag: N/A
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol.
• Molecular Mass: 15.5 kDa (134aa), confirmed by MALDI-TOF.
• Protein length: 43-175aa
• AA Sequence: MAQDQTQDTQ LITVDEKLDI TTLTGVPEEH IKTRKVRIFV PARNNMQSGV NNTKKWKMEF DTRERWENPL MGWASTADPL SNMVLTFSTK EDAVSFAEKN GWSYDIEERK VPKPKSKSYG ANFSWNKRTR VSTK
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) [ Homo sapiens ]
• Official Symbol: NDUFS4
• Synonyms: NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 4 (18kD) (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; AQDQ; CI 18; complex I 18kDa subunit; CI-AQDQ; CI-18 kDa; complex I-AQDQ; complex I-18 kDa; NADH-coenzyme Q reductase, 18-KD; NADH-ubiquinone oxidoreductase 18 kDa subunit; NADH dehydrogenase (ubiquinone) iron-sulfur protein 4; mitochondrial respiratory chain complex I (18-KD subunit); CI-18
• Gene ID: 4724
• mRNA Refseq: NM_002495
• Protein Refseq: NP_002486
• MIM: 602694
• UniProt ID: O43181
• Chromosome Location: 5q11.1
• Pathway: Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Electron Transport Chain, organism-specific biosystem; Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem
• Function: NADH dehydrogenase (ubiquinone) activity; contributes_to NADH dehydrogenase (ubiquinone) activity; oxidoreductase activity, acting on NADH or NADPH