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Recombinant Human APAF1 Interacting Protein, His-tagged

Cat.No. : APIP-6855H
Product Overview : Recombinant human APIP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
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  • Gene Information
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Description : APIP catalyzes the dehydration of methylthioribulose-1-phosphate into 2,3-diketo-5-methylthiopentyl-1-phosphate. It has an anti-apoptotic function and prevents muscle ischemic damage. This protein inhibits the cytochrome c-dependent and APAF1-mediated cell death.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT.
Molecular Mass : 29.7 kDa (266aa) confirmed by MALDI-TOF
Protein length : 1-242aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSHMSGCDA REGDCCSRRC GAQDKEHPRY LIPELCKQFY HLGWVTGTGG GISLKHGDEI YIAPSGVQKE RIQPEDMFVC DINEKDISGP SPSKKLKKSQ CTPLFMNAYT MRGAGAVIHT HSKAAVMATL LFPGREFKIT HQEMIKGIKK CTSGGYYRYD DMLVVPIIEN TPEEKDLKDR MAHAMNEYPD SCAVLVRRHG VYVWGETWEK AKTMCECYDY LFDIAVSMKK VGLDPSQLPV GENGIV
Purity : >85% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -76°C. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/ml (determined by Bradford assay)
Gene Name : APIP APAF1 interacting protein [ Homo sapiens ]
Official Symbol : APIP
Synonyms : APIP; APAF1 interacting protein; probable methylthioribulose-1-phosphate dehydratase; APIP2; CGI 29; Mmrp19; MTRu-1-P dehydratase; APAF1-interacting protein; CGI29; CGI-29; MMRP19; dJ179L10.2;
Gene ID : 51074
mRNA Refseq : NM_015957
Protein Refseq : NP_057041
MIM : 612491
UniProt ID : Q96GX9
Chromosome Location : 11p13
Pathway : Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Metabolism of polyamines, organism-specific biosystem; Methionine salvage pathway, organism-specific biosystem;
Function : identical protein binding; ion binding; lyase activity; metal ion binding; methylthioribulose 1-phosphate dehydratase activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (19)

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Does Apip produce immunogenicity? 12/03/2022

The recombinant Apip protein is low in immunogenicity and has not been found to produce any immune response to the body.

What is the application prospect of Apip in drug development? 12/02/2022

The recombinant Apip protein has potential applications in drug development and can be used to make drugs for the treatment of platelet dysfunction.

What are the physical and chemical properties of Apip ? 11/15/2022

The physicochemical properties of Apip are a very stable protein that can adapt to a variety of pH values and temperatures.

Which diseases can Apip be used to treat? 10/07/2022

Apip protein can be used to treat platelet dysfunction, influenza virus and other related diseases.

How is Apip used in diagnosis? 07/30/2022

The Apip can be used to diagnose influenza virus infection by detecting the level of antibodies to the Apip .

What is the mechanism of action of Apip in the treatment of platelet dysfunction? 07/06/2022

Recombinant Apip protein can enhance the adhesion of platelets by activating the polymers on the surface of platelets, thus treating platelet dysfunction.

How is Apip prepared? 05/05/2022

First, the target gene needs to be cloned into the expression vector, and then expressed in E. coli and other hosts, and the recombinant Apip protein can be obtained after purification and refolding.

Recombinant Apip protein can be used to make drugs for the treatment of platelet dysfunction. What is its effect? 09/12/2021

The recombinant Apip protein has been clinically tested in patients as a drug for the treatment of platelet dysfunction, and the results show that it has some efficacy in the treatment of this disease.

Can Apip be degraded by digestive enzymes? 08/18/2021

Apip can maintain relative stability under the action of digestive enzymes such as stomach acid and pancreatic enzyme, and is not easy to be degraded.

What is the difference between Apip and other similar molecules? 06/19/2021

The Apip differs from other similar molecules in that it is a highly stable protein that can remain intact under extreme conditions.

What is the safety of Apip in clinical trials? 02/11/2021

Clinical trials of Apip have shown a high safety profile without any serious adverse reactions.

What is the safety of Apip ? 08/26/2020

The safety of Apip is very high, and no adverse effects on the body have been found in animal experiments.

What are the application areas of Apip ? 05/06/2020

Apip can be used in the production of antitoxins, vaccines and other fields.

What are the characteristics of Apip s compared with other s? 01/12/2020

Apip s are characterized by being more stable in high temperature and acid-base environments, which makes them more advantageous in some special application scenarios.

What is the effect of Apip in animal experiments? 01/08/2020

Recombinant Apip protein can significantly increase platelet count and shorten bleeding time and hemostasis time in animal experiments.

What is the production cost of Apip ? 04/08/2019

The production cost of Apip varies according to different factors such as production scale and process, and is generally at a moderate level.

How toxic is Apip ? 02/27/2019

The Apip is a very safe protein with low toxicity.

What is the role of Apip in medical research? 02/23/2019

Apip can be used to cause diseases such as asthma, influenza, bronchitis and other models for the study of drugs to treat various related diseases.

What are the biological characteristics of Apip ? 02/09/2019

The Apip is a very stable protein that can remain intact under extreme conditions such as acid-base environments and high temperatures.

Customer Reviews (5)

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Reviews
12/03/2022

    Experimenting with this Apip allows me to focus more on experimental design and data analysis without worrying about reproducibility of experimental results.

    06/19/2021

      Production process of Apip is an environmental model and sets an example for the field of green production.

      06/28/2020

        Under the action of various chemical agents or drugs, the stability of this protein is still very good, indicating that it has excellent anti-interference ability.

        04/11/2020

          The lower limit of detection of Apip in Western blot is very low, and low concentration of target protein can be detected, indicating that it has the characteristics of high sensitivity and low detection limit.

          05/23/2019

            This short half-life and high clearance characteristics make Apip have greater potential in the treatment of tumors, infections and other diseases.

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