"TPSAB1" Related Products

Recombinant Human Tryptase Alpha/Beta 1, His-tagged

Cat.No.: TPSAB1-7161H
Product Overview: Recombinant human TPSAB1 protein, fused to His-tag at N-terminus, was expressed in E. coli. MW: 30.1 kDa.
Description: TPSAB1, also known as tryptase alpha/beta-1, is a tryptase that is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It is enzymatically active only as a heparin-stabilized tetramer, and it is resistant to all known an endogenous proteinase inhibitor. This protein has been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea.
Molecular Mass: 30.1 kDa(270aa)
Protein length: 31-275aa
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMIVGGQ EAPRSKWPWQ VSLRVHGPYW MHFCGGSLIH PQWVLTAAHC VGPDVKDLAA LRVQLREQHL YYQDQLLPVS RIIVHPQFYT AQIGADIALL ELEEPVNVSS HVHTVTLPPA SETFPPGMPC WVTGWGDVDN DERLPPPFPL KQVKVPIMEN HICDAKYHLG AYTGDDVRIV RDDMLCAGNT RRDSCQGDSG GPLVCKVNGT WLQAGVVSWG EGCAQPNRPG IYTRVTYYLD WIHHYVPKKP
Purity: >85% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration: 1.0 mg/ml (determined by Bradford assay)
Gene Name: TPSAB1 tryptase alpha/beta 1 [ Homo sapiens ]
Official Symbol: TPSAB1
Synonyms: TPSAB1; tryptase alpha/beta 1; TPS1, TPS2, TPSB1, tryptase beta 1; tryptase alpha/beta-1; tryptase alpha II; tryptase beta I; tryptase I; tryptase II; tryptase III; tryptase-1; tryptase-I; tryptase-III; tryptase beta 1; tryptase beta-1; tryptase alpha-1; mast cell beta I tryptase; mast cell alpha II tryptase; TPS1; TPS2; TPSB1; MGC104064;
Gene ID: 7177
mRNA Refseq: NM_003294
Protein Refseq: NP_003285
MIM: 191080
UniProt ID: Q15661
Chromosome Location: 16p13.3
Pathway: Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem;
Function: peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity;

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