Recombinant Human TPSAB1 Protein, His-tagged

• Cat.No.: TPSAB1-241H
• Product Overview: Recombinant Human TPSAB1(31-275aa) fused with His tag at C-terminal was expressed in Insect cells.

Specification

• Description: TPSAB1, also known as tryptase alpha/beta-1, is a serine protease with trypsin-like specificity. It is the key neutral protease present in mast cells and is discharged upon the coupled activation-degranulation response of this cell type. This protein is enzymatically active only as a heparin-stabilized tetramer, and is resistant to all known endogenous proteinase inhibitors. Also, it is implicated as a mediator in the pathogenesis of asthma and other allergic and inflammatory disorders.
• Source: Insect cells
• Species: Human
• Tag: His
• Predicted N Terminal: Ile31
• Form: Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
• Molecular Mass: 28.2kDa (251aa) 28-40kDa (SDS-PAGE under reducing conditions)
• Protein length: 31-275aa
• AA Sequence: IVGGQEAPRS KWPWQVSLRV HGPYWMHFCG GSLIHPQWVL TAAHCVGPDV KDLAALRVQL REQHLYYQDQ LLPVSRIIVH PQFYTAQIGA
  DIALLELEEP VNVSSHVHTV TLPPASETFP PGMPCWVTGW GDVDNDERLP PPFPLKQVKV PIMENHICDA KYHLGAYTGD DVRIVRDDML
  CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG VVSWGEGCAQ PNRPGIYTRV TYYLDWIHHY VPKKPHHHHH H
• Purity: > 90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Absorbance at 280)

Gene Information

• Gene Name: TPSAB1 tryptase alpha/beta 1 [ Homo sapiens ]
• Official Symbol: TPSAB1
• Synonyms: TPSAB1; tryptase alpha/beta 1; TPS1, TPS2, TPSB1, tryptase beta 1; tryptase alpha/beta-1; tryptase alpha II; tryptase beta I; tryptase I; tryptase II; tryptase III; tryptase-1; tryptase-I; tryptase-III; tryptase beta 1; tryptase beta-1; tryptase alpha-1; mast cell beta I tryptase; mast cell alpha II tryptase; TPS1; TPS2; TPSB1; MGC104064
• Gene ID: 7177
• mRNA Refseq: NM_003294
• Protein Refseq: NP_003285
• MIM: 191080
• UniProt ID: Q15661