Recombinant Human Asialoglycoprotein Receptor 2, His-tagged

• Cat.No.: ASGR2-7208H
• Product Overview: Recombinant human ASGR2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 28.9 kDa.

Specification

• Description: ASGR2 is a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. It may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. ASGR2 is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. ASGR2 is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 30% glycerol, 1mM DTT.
• Molecular Mass: 28.9 kDa (255aa) confirmed by MALDI-TOF
• Protein length: 80-311aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSQSEGHRG AQLQAELRSL KEAFSNFSSS TLTEVQAIST HGGSVGDKIT SLGAKLEKQQ QDLKADHDAL LFHLKHFPVD LRFVACQMEL LHSNGSQRTC CPVNWVEHQG SCYWFSHSGK AWAEAEKYCQ LENAHLVVIN SWEEQKFIVQ HTNPFNTWIG LTDSDGSWKW VDGTDYRHNY KNWAVTQPDN WHGHELGGSE DCVEVQPDGR WNDDFCLQVY RWVCEKRRNA TGEVA
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: ASGR2 asialoglycoprotein receptor 2 [ Homo sapiens ]
• Official Symbol: ASGR2
• Synonyms: ASGR2; asialoglycoprotein receptor 2; CLEC4H2; hepatic lectin H2; HBxAg-binding protein; C-type lectin domain family 4 member H2; HL-2; HBXBP; ASGPR2; ASGP-R2; FLJ60040
• Gene ID: 433
• mRNA Refseq: NM_001181
• Protein Refseq: NP_001172
• MIM: 108361
• UniProt ID: P07307
• Chromosome Location: 17p
• Function: asialoglycoprotein receptor activity; protein binding; receptor activity; sugar binding