"CABLES1" Related Products

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Recombinant Human ABL1 (Active), GST-tagged

Cat.No.: CABLES1-1361H
Product Overview: Recombinant human ABL1 (G250E) (27-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: ABL1protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of ABL protein is negatively regulated by its SH3 domain and deletion of the SH3 domain turns ABL1 into an oncogene. Translocation and head-to-tail fusion of the BCR and ABL1 genes is present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDK1-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 6 nmol/min/mg
Molecular Mass: ~160 kDa
Protein length: 27 aa-end
Purity: >70%
Applications: Kinase Assay, Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1 μg/μl
Gene Name: CABLES1 Cdk5 and Abl enzyme substrate 1 [ Homo sapiens ]
Official Symbol: CABLES1
Synonyms: CABLES1; Cdk5 and Abl enzyme substrate 1; CDK5 and ABL1 enzyme substrate 1; FLJ35924; HsT2563; interactor with CDK3 1; CABL1; IK3-1; CABLES;
Gene ID: 91768
mRNA Refseq: NM_001100619
Protein Refseq: NP_001094089
MIM: 609194
UniProt ID: Q8TDN4
Chromosome Location: 18q11.2
Pathway: Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function: cyclin-dependent protein kinase regulator activity;

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