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Recombinant Human AKT2 (Active), His-tagged

Cat.No.: AKT2-1364H
Product Overview: Recombinant full-length human AKT2 was expressed by baculovirus in Sf9 insect cells using a N-terminal His tag.
Description: AKT2 or Protein Kinase B β (PKBβ) is a serine/threonine kinase that is a member of the AKT family. AKT2 like the other AKT members is activated in cells in response to diverse stimuli such as hormones, growth factors and extracellular matrix components and is involved in glucose metabolism, transcription, survival, cell proliferation, angiogenesis, and cell motility. The PI3K generates phosphatidylinositol-3,4,5-trisphosphate (PIP3), a lipid second messenger essential for the translocation of AKT2 to the plasma membrane where it is phosphorylated and activated by phosphoinositide-dependent kinase-1 (PDK-1).
Source: Sf9 Cells
Species: Human
Tag: His
Form: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 2mM DTT, 25% glycerol.
Bio-activity: 40 nmol/min/mg
Molecular Mass: ~58 kDa
Protein length: Full length
Purity: >70%
Applications: Kinase Assay, Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: AKT2 v-akt murine thymoma viral oncogene homolog 2 [ Homo sapiens ]
Official Symbol: AKT2
Synonyms: AKT2; v-akt murine thymoma viral oncogene homolog 2; RAC-beta serine/threonine-protein kinase; PKB beta; RAC-PK-beta; protein kinase Akt-2; protein kinase B beta; rac protein kinase beta; murine thymoma viral (v-akt) homolog-2; PKBB; PRKBB; HIHGHH; PKBBETA; RAC-BETA;
Gene ID: 208
mRNA Refseq: NM_001243027
Protein Refseq: NP_001229956
MIM: 164731
UniProt ID: P31751
Chromosome Location: 19q13.1-q13.2
Pathway: AKT phosphorylates targets in the cytosol, organism-specific biosystem; AKT phosphorylates targets in the nucleus, organism-specific biosystem; AKT-mediated inactivation of FOXO1A, organism-specific biosystem; Activation of PKB, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem;
Function: ATP binding; ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase C binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity;

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