"IBTK" Related Products

Recombinant Human BTK (Active), His-tagged

Cat.No. : IBTK-1370H
Product Overview : Recombinant full-length human BTK was expressed by baculovirus in Sf9 insect cells using a N-terminal His tag.
Description : BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors. Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments.
Source : Sf9 Cells
Species : Human
Tag : His
Form : Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.2mM DTT, 25% glycerol.
Bio-activity : 43 nmol/min/mg
Molecular Mass : ~78 kDa
Protein length : Full length
Purity : >90%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1 μg/μl
Gene Name : IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase [ Homo sapiens ]
Official Symbol : IBTK
Synonyms : IBTK; inhibitor of Bruton agammaglobulinemia tyrosine kinase; Bruton agammaglobulinemia tyrosine kinase inhibitor , BTKI; inhibitor of Bruton tyrosine kinase; DKFZP564B116; BTK-binding protein; inhibitor of Brutons tyrosine kinase; inhibitor of Brutons tyrosine kinase-beta; inhibitor of Brutons tyrosine kinase-alpha; inhibitor of Brutons tyrosine kinase-gamma; Bruton agammaglobulinemia tyrosine kinase inhibitor; BTKI; RP1-93K22.1; KIAA1417; MGC142256; MGC142258;
Gene ID : 25998
mRNA Refseq : NM_015525
Protein Refseq : NP_056340
MIM : 606457
UniProt ID : Q9P2D0
Chromosome Location : 6q14.3
Pathway : BCR signaling pathway, organism-specific biosystem;
Function : protein kinase binding; protein tyrosine kinase inhibitor activity;

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