Active Recombinant Human BTK, His-tagged
Cat.No. : | IBTK-1370H |
Product Overview : | Recombinant full-length human BTK was expressed by baculovirus in Sf9 insect cells using a N-terminal His tag. |
- Specification
- Gene Information
- Related Products
Description : | BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors. Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | His |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.2mM DTT, 25% glycerol. |
Bio-activity : | 43 nmol/min/mg |
Molecular Mass : | ~78 kDa |
Protein length : | Full length |
Purity : | >90% |
Applications : | Kinase Assay, Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1 μg/μl |
Gene Name : | IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase [ Homo sapiens ] |
Official Symbol : | IBTK |
Synonyms : | IBTK; inhibitor of Bruton agammaglobulinemia tyrosine kinase; Bruton agammaglobulinemia tyrosine kinase inhibitor , BTKI; inhibitor of Bruton tyrosine kinase; DKFZP564B116; BTK-binding protein; inhibitor of Brutons tyrosine kinase; inhibitor of Brutons tyrosine kinase-beta; inhibitor of Brutons tyrosine kinase-alpha; inhibitor of Brutons tyrosine kinase-gamma; Bruton agammaglobulinemia tyrosine kinase inhibitor; BTKI; RP1-93K22.1; KIAA1417; MGC142256; MGC142258; |
Gene ID : | 25998 |
mRNA Refseq : | NM_015525 |
Protein Refseq : | NP_056340 |
MIM : | 606457 |
UniProt ID : | Q9P2D0 |
Chromosome Location : | 6q14.3 |
Pathway : | BCR signaling pathway, organism-specific biosystem; |
Function : | protein kinase binding; protein tyrosine kinase inhibitor activity; |
Products Types
◆ Recombinant Protein | ||
IBTK-4401M | Recombinant Mouse IBTK Protein, His (Fc)-Avi-tagged | +Inquiry |
IBTK-354C | Recombinant Cynomolgus Monkey IBTK Protein, His (Fc)-Avi-tagged | +Inquiry |
IBTK-7967M | Recombinant Mouse IBTK Protein | +Inquiry |
IBTK-608C | Recombinant Cynomolgus IBTK Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IBTK-5317HCL | Recombinant Human IBTK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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