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Recombinant Human HCK (Active), GST-tagged

Cat.No.: HCK-1412H
Product Overview: Recombinant human HCK (230-497) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Description: HCK, a protein-tyrosine kinase belonging to the Src family, is expressed in certain hemopoietic cells and especially prominent in cells of myeloid lineage, particularly mature granulocytes and monocytes. HCK gene is located on chromosome sequence 20q11-q12, a region that is affected by interstitial deletions in some acute myeloid leukemias and myeloproliferative disorders suggesting damage to HCK may contribute to the pathogenesis of these conditions.
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity: 171 nmol/min/mg
Molecular Mass: ~57 kDa
Protein length: 230-497 aa
Purity: >90%
Applications: Kinase Assay, Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: HCK hemopoietic cell kinase [ Homo sapiens ]
Official Symbol: HCK
Synonyms: HCK; hemopoietic cell kinase; tyrosine-protein kinase HCK; JTK9; p59-HCK/p60-HCK; hematopoietic cell kinase; p59Hck; p61Hck;
Gene ID: 3055
mRNA Refseq: NM_001172129
Protein Refseq: NP_001165600
MIM: 142370
UniProt ID: P08631
Chromosome Location: 20q11-q12
Pathway: Alpha-synuclein signaling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class I PI3K signaling events, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem;
Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein tyrosine kinase activity;

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