"ITK" Related Products

Expand
Expand

Recombinant Human ITK (Active), GST-tagged

Cat.No. : ITK-1419H
Product Overview : Recombinant human ITK (352-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : ITK is a member of the TEC family of non-receptor tyrosine kinases. ITK is expressed in T-cells and is important for T-cell development and activation through the antigen receptor.ITK require prior activation of Lck, Zap-70 and PI3-kinase for efficient activation and shares major substrates with both Lck and Zap-70. ITK knockout mice show multiple effects on T cell development, cytokine production and T-helper cell differentiation. T cells that lack or express mutant versions of ITK show impaired TCR-induced actin polymerization, cell polarization and regulation of the signaling events involved in cytoskeletal reorganization.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity : 58 nmol/min/mg
Molecular Mass : ~53 kDa
Protein length : 352 aa-end
Purity : >90%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : ITK IL2-inducible T-cell kinase [ Homo sapiens ]
Official Symbol : ITK
Synonyms : ITK; IL2-inducible T-cell kinase; tyrosine-protein kinase ITK/TSK; EMT; LYK; PSCTK2; kinase EMT; T-cell-specific kinase; tyrosine-protein kinase LYK; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; homolog of mouse T-cell itk/tsk; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; MGC126257; MGC126258;
Gene ID : 3702
mRNA Refseq : NM_005546
Protein Refseq : NP_005537
MIM : 186973
UniProt ID : Q08881
Chromosome Location : 5q31-q32
Pathway : Adaptive Immune System, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class I PI3K signaling events, organism-specific biosystem; Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem; Generation of second messenger molecules, organism-specific biosystem;
Function : ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.