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Recombinant Human LCK (Active), GST-tagged

Cat.No.: LCK-1424H
Product Overview: Recombinant full-length human LCK was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Description: LCK (p56lck) is a member of the src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene. Lck behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show overexpression of LCK, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers.
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity: 239 nmol/min/mg
Molecular Mass: ~84 kDa
Protein length: Full length
Purity: >90%
Applications: Kinase Assay, Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: LCK lymphocyte-specific protein tyrosine kinase [ Homo sapiens ]
Official Symbol: LCK
Synonyms: LCK; lymphocyte-specific protein tyrosine kinase; tyrosine-protein kinase Lck; leukocyte C-terminal Src kinase; p56(LSTRA) protein-tyrosine kinase; t cell-specific protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; lymphocyte cell-specific protein-tyrosine kinase; T-lymphocyte specific protein tyrosine kinase p56lck; LSK; YT16; p56lck; pp58lck;
Gene ID: 3932
mRNA Refseq: NM_001042771
Protein Refseq: NP_001036236
MIM: 153390
UniProt ID: P06239
Chromosome Location: 1p34.3
Pathway: Adaptive Immune System, organism-specific biosystem; Alpha-synuclein signaling, organism-specific biosystem; Atypical NF-kappaB pathway, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CD28 co-stimulation, organism-specific biosystem; CD28 dependent PI3K/Akt signaling, organism-specific biosystem; CD28 dependent Vav1 pathway, organism-specific biosystem;
Function: ATP binding; ATPase binding; CD4 receptor binding; CD8 receptor binding; SH2 domain binding; SH2 domain binding; antigen binding; glycoprotein binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; protein C-terminus binding; protein binding; protein complex binding; protein kinase binding; protein serine/threonine phosphatase activity; protein serine/threonine phosphatase activity; protein tyrosine kinase activity; protein tyrosine kinase activity; protein tyrosine kinase activity; protein tyrosine kinase activity; protein tyrosine phosphatase activity;

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