Active Recombinant Human NUAK1, GST-tagged
Cat.No. : | NUAK1-1439H |
Product Overview : | Recombinant full-length human NUAK1 (ARK5) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | NUAK1 or SNF1/AMP kinase-related kinase (SNARK) is a member of the NUAK family of SNF1-like kinase 1 that is also known as AMPK-related protein kinase 5 (ARK5). ARK5 is a tumor cell survival factor that is activated by AKT and acts as an ATM kinase under conditions of nutrient starvation. NUAK1 is highly expressed in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung, and liver. NUAK1 is involved in tolerance to glucose starvation and suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 50 nmol/min/mg |
Molecular Mass : | ~122 kDa |
Protein length : | Full length |
Purity : | >80% |
Applications : | Kinase Assay, Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | NUAK1 NUAK family, SNF1-like kinase, 1 [ Homo sapiens ] |
Official Symbol : | NUAK1 |
Synonyms : | NUAK1; NUAK family, SNF1-like kinase, 1; NUAK family SNF1-like kinase 1; AMP activated protein kinase family member 5; ARK5; KIAA0537; NuaK1; omphalocele kinase 1; AMPK-related protein kinase 5; AMP-activated protein kinase family member 5; |
Gene ID : | 9891 |
mRNA Refseq : | NM_014840 |
Protein Refseq : | NP_055655 |
MIM : | 608130 |
UniProt ID : | O60285 |
Chromosome Location : | 12q23.3 |
Function : | ATP binding; metal ion binding; nucleotide binding; p53 binding; protein binding; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
NUAK1-6238M | Recombinant Mouse NUAK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NUAK1-1132H | Recombinant Human NUAK1 Protein (E2-N661), Tag Free | +Inquiry |
NUAK1-1133H | Recombinant Human NUAK1 Protein (E2-N661), GST tagged | +Inquiry |
NUAK1-1921H | Recombinant Human NUAK1 protein, His & T7-tagged | +Inquiry |
NUAK1-10949M | Recombinant Mouse NUAK1 Protein | +Inquiry |
◆ Lysates | ||
NUAK1-3665HCL | Recombinant Human NUAK1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionMutations in the NUAK1 gene have been identified in certain cancers and may have implications for prognosis and treatment response.
Yes, several preclinical studies have identified potential drug candidates that target NUAK1 protein for cancer therapy.
NUAK1 protein has been shown to regulate stress responses in cells, including responses to oxidative stress and DNA damage.
Potential side effects may include off-target effects on other cellular processes and toxicity to normal cells.
Targeting NUAK1 protein may have implications for conditions related to stress responses, such as neurodegenerative diseases and aging-related disorders.
Customer Reviews (3)
Write a reviewThe NUAK1 protein is an exceptional product that meets the highest standards of quality, making it an ideal choice to fulfill my experimental requirements.
By incorporating the NUAK1 protein into electron microscopy studies, researchers gain insights into the intricate three-dimensional architecture of proteins, facilitating a deeper comprehension of their functions and aiding in the development of novel therapeutics.
Its reliability and effectiveness in generating accurate data make it an indispensable resource, driving scientific exploration and advancing our understanding of protein structure and function
Ask a Question for All NUAK1 Products
Required fields are marked with *
My Review for All NUAK1 Products
Required fields are marked with *
Inquiry Basket