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Active Recombinant Human NUAK1, GST-tagged

Cat.No. : NUAK1-1439H
Product Overview : Recombinant full-length human NUAK1 (ARK5) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Description : NUAK1 or SNF1/AMP kinase-related kinase (SNARK) is a member of the NUAK family of SNF1-like kinase 1 that is also known as AMPK-related protein kinase 5 (ARK5). ARK5 is a tumor cell survival factor that is activated by AKT and acts as an ATM kinase under conditions of nutrient starvation. NUAK1 is highly expressed in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung, and liver. NUAK1 is involved in tolerance to glucose starvation and suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 50 nmol/min/mg
Molecular Mass : ~122 kDa
Protein length : Full length
Purity : >80%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : NUAK1 NUAK family, SNF1-like kinase, 1 [ Homo sapiens ]
Official Symbol : NUAK1
Synonyms : NUAK1; NUAK family, SNF1-like kinase, 1; NUAK family SNF1-like kinase 1; AMP activated protein kinase family member 5; ARK5; KIAA0537; NuaK1; omphalocele kinase 1; AMPK-related protein kinase 5; AMP-activated protein kinase family member 5;
Gene ID : 9891
mRNA Refseq : NM_014840
Protein Refseq : NP_055655
MIM : 608130
UniProt ID : O60285
Chromosome Location : 12q23.3
Function : ATP binding; metal ion binding; nucleotide binding; p53 binding; protein binding; protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any genetic mutations associated with NUAK1 protein that have clinical implications? 08/27/2019

Mutations in the NUAK1 gene have been identified in certain cancers and may have implications for prognosis and treatment response.

Are there any drugs targeting NUAK1 protein in cancer treatment? 06/15/2018

Yes, several preclinical studies have identified potential drug candidates that target NUAK1 protein for cancer therapy.

How does NUAK1 protein affect stress responses in cells? 01/28/2018

NUAK1 protein has been shown to regulate stress responses in cells, including responses to oxidative stress and DNA damage.

Are there any side effects associated with targeting NUAK1 protein in clinical applications? 01/28/2017

Potential side effects may include off-target effects on other cellular processes and toxicity to normal cells.

What are the potential therapeutic implications of targeting NUAK1 protein in stress-related conditions? 09/17/2016

Targeting NUAK1 protein may have implications for conditions related to stress responses, such as neurodegenerative diseases and aging-related disorders.

Customer Reviews (3)

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Reviews
12/15/2018

    The NUAK1 protein is an exceptional product that meets the highest standards of quality, making it an ideal choice to fulfill my experimental requirements.

    05/06/2017

      By incorporating the NUAK1 protein into electron microscopy studies, researchers gain insights into the intricate three-dimensional architecture of proteins, facilitating a deeper comprehension of their functions and aiding in the development of novel therapeutics.

      03/14/2016

        Its reliability and effectiveness in generating accurate data make it an indispensable resource, driving scientific exploration and advancing our understanding of protein structure and function

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