"SIK2" Related Products

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Recombinant Human QIK (Active), GST-tagged

Cat.No.: SIK2-1478H
Product Overview: Recombinant full-length human QIK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: QIK is a serine/threonine protein kinase that contains an N-terminal kinase domain, a central domain with ubiquitin-associate motif, and a C-terminal PKAphosphorylation site. QIK can phosphorylate IRS1 and overexpression of QIK in adipocyte elevates the phosphorylation of IRS1. The QIK-mediated phosphorylation of IRS1 may modulate the efficiency of insulin signal transduction and could be responsible for insulin resistance associated with diabetes. Insulin disrupts TORC2 activity by induction of QIK which then stimulates the phosphorylation and cytoplasmic translocation of TORC2. Phosphorylated TORC2 is subsequently degraded by the 26S proteasome.
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 112 nmol/min/mg
Molecular Mass: ~150 kDa
Protein length: Full length
Purity: >70%
Applications: Kinase Assay, Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: SIK2 salt-inducible kinase 2 [ Homo sapiens ]
Official Symbol: SIK2?
Synonyms: SIK2; salt-inducible kinase 2; SNF1 like kinase 2 , SNF1LK2; serine/threonine-protein kinase SIK2; DKFZp434K1115; KIAA0781; LOH11CR1I; QIK; SIK-2; SNF1-like kinase 2; qin-induced kinase; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; serine/threonine-protein kinase SNF1-like kinase 2; SNF1LK2;
Gene ID: 23235
mRNA Refseq: NM_015191
Protein Refseq: NP_056006
MIM: 608973
UniProt ID: Q9H0K1
Chromosome Location: 11q23.1
Pathway: LKB1 signaling events, organism-specific biosystem;
Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity;

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