Active Recombinant Human STK39, His-tagged

• Cat.No.: STK39-1490H
• Product Overview: Recombinant full-length human STK39 (STLK3) was expressed using baculovirus in Sf9 insect cells using an N-terminal His tag.

Specification

• Description: STK39 (also known as serine threonine kinase 39) is involved in the cellular stress response pathway. STK39 is activated in response to hypotonic stress leading to phosphorylation of several cation-chloride-coupled co-transporters. STK39 activates the p38 MAP kinase pathway and its interaction with p38 decreases during cellular stress. STK39 acts as an intermediate in the response to cellular stress. STK39 is also an independent risk factor for hypertension in men and its intragenic SNPs can interact and function in the control of blood pressure.
• Source: Sf9 Cells
• Species: Human
• Tag: His
• Form: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
• Bio-activity: 22 nmol/min/mg
• Molecular Mass: ~63 kDa
• Protein length: Full length
• Purity: >95%
• Applications: Kinase Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: STK39 serine threonine kinase 39 [ Homo sapiens ]
• Official Symbol: STK39
• Synonyms: STK39; serine threonine kinase 39; STE20/SPS1-related proline-alanine-rich protein kinase; DCHT; SPAK; STE20/SPS1 homolog (yeast); STE20/SPS1 homolog; ste-20-related kinase; Ste20-like protein kinase; small intestine SPAK-like kinase; serine/threonine-protein kinase 39; proline-alanine-rich STE20-related kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); PASK; DKFZp686K05124
• Gene ID: 27347
• mRNA Refseq: NM_013233
• Protein Refseq: NP_037365
• MIM: 607648
• UniProt ID: Q9UEW8
• Chromosome Location: 2q24.3
• Pathway: T Cell Receptor Signaling Pathway, organism-specific biosystem; TCR signaling in naive CD4+ T cells, organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein kinase binding; receptor signaling protein serine/threonine kinase activity