Active Recombinant Human TXK, GST-tagged

• Cat.No.: TXK-1504H
• Product Overview: Recombinant human TXK (239-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: TXK or RLK is a member of the TEC family of non-receptor tyrosine kinases. TXK is expressed in T-cells and is an important component of signaling pathways downstream of lymphocyte antigen receptor.TXK is phosphorylated in response to T-cell receptor stimulation and can be activated by phosphorylation by Src family kinases. However, TXK is phosphorylated independent of PI-3K activity. Excessive TXK protein expression is seen in patients with Behcets disease. Over production of TXK leads to increased Th1 cell function that is involved in the pathogenesis of Behcet?s disease.
• Source: Sf9 Cells
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 18 nmol/min/mg
• Molecular Mass: ~53 kDa
• Protein length: 239 aa-end
• Purity: >90%
• Applications: Kinase Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: TXK TXK tyrosine kinase [ Homo sapiens ]
• Official Symbol: TXK
• Synonyms: TXK; TXK tyrosine kinase; PTK4, PTK4 protein tyrosine kinase 4; tyrosine-protein kinase TXK; BTKL; PSCTK5; RLK; TKL; tyrosine kinase; protein-tyrosine kinase 4; resting lymphocyte kinase; PTK4 protein tyrosine kinase 4; PTK4; MGC22473
• Gene ID: 7294
• mRNA Refseq: NM_003328
• Protein Refseq: NP_003319
• MIM: 600058
• UniProt ID: P42681
• Chromosome Location: 4p12
• Pathway: Focal Adhesion, organism-specific biosystem; Leukocyte transendothelial migration, organism-specific biosystem; Leukocyte transendothelial migration, conserved biosystem; T Cell Receptor Signaling Pathway, organism-specific biosystem
• Function: ATP binding; DNA binding; RNA polymerase II regulatory region DNA binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding