Recombinant Human TXK (Active), GST-tagged


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Recombinant Human TXK (Active), GST-tagged

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Cat.No. : TXK-1504H
Product Overview : Recombinant human TXK (239-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : TXK or RLK is a member of the TEC family of non-receptor tyrosine kinases. TXK is expressed in T-cells and is an important component of signaling pathways downstream of lymphocyte antigen receptor.TXK is phosphorylated in response to T-cell receptor stimulation and can be activated by phosphorylation by Src family kinases. However, TXK is phosphorylated independent of PI-3K activity. Excessive TXK protein expression is seen in patients with Behcets disease. Over production of TXK leads to increased Th1 cell function that is involved in the pathogenesis of Behcet?s disease.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity : 18 nmol/min/mg
Molecular Mass : ~53 kDa
Protein length : 239 aa-end
Purity : >90%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : TXK TXK tyrosine kinase [ Homo sapiens ]
Official Symbol : TXK
Synonyms : TXK; TXK tyrosine kinase; PTK4, PTK4 protein tyrosine kinase 4; tyrosine-protein kinase TXK; BTKL; PSCTK5; RLK; TKL; tyrosine kinase; protein-tyrosine kinase 4; resting lymphocyte kinase; PTK4 protein tyrosine kinase 4; PTK4; MGC22473;
Gene ID : 7294
mRNA Refseq : NM_003328
Protein Refseq : NP_003319
MIM : 600058
UniProt ID : P42681
Chromosome Location : 4p12
Pathway : Focal Adhesion, organism-specific biosystem; Leukocyte transendothelial migration, organism-specific biosystem; Leukocyte transendothelial migration, conserved biosystem; T Cell Receptor Signaling Pathway, organism-specific biosystem;
Function : ATP binding; DNA binding; RNA polymerase II regulatory region DNA binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding;

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