Active Recombinant Human PTPN11, GST-tagged

• Cat.No.: PTPN11-1518H
• Product Overview: Recombinant human PTPN11 (246-593) was expressed in Sf9 Insect Cells using a N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 246-593 aa
• Description: Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration
• Form: Recombinant protein stored in 20 mM MOPS, pH 7.5, 50 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 30% glycerol.
• Bio-activity: 597 nmol/min/mg
• Molecular Mass: ~69 kDa
• Purity: >90%
• Applications: Phosphatase Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: PTPN11 protein tyrosine phosphatase, non-receptor type 11 [ Homo sapiens ]
• Official Symbol: PTPN11
• Synonyms: PTPN11; protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433
• Gene ID: 5781
• mRNA Refseq: NM_002834
• Protein Refseq: NP_002825
• MIM: 176876
• UniProt ID: Q06124
• Chromosome Location: 12q24.1
• Pathway: Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Axon guidance, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CTLA4 inhibitory signaling, organism-specific biosystem
• Function: hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; protein binding; protein tyrosine phosphatase activity