"PTPN11" Related Products

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Recombinant Human PTPN11 (Active), GST-tagged

Cat.No.: PTPN11-1518H
Product Overview: Recombinant human PTPN11 (246-593) was expressed in E.coli cells using a N-terminal GST tag.
Description: Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 20 mM MOPS, pH 7.5, 50 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 30% glycerol.
Bio-activity: 597 nmol/min/mg
Molecular Mass: ~69 kDa
Protein length: 246-593 aa
Purity: >90%
Applications: Phosphatase Assay, Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: PTPN11 protein tyrosine phosphatase, non-receptor type 11 [ Homo sapiens ]
Official Symbol: PTPN11
Synonyms: PTPN11; protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433;
Gene ID: 5781
mRNA Refseq: NM_002834
Protein Refseq: NP_002825
MIM: 176876
UniProt ID: Q06124
Chromosome Location: 12q24.1
Pathway: Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Axon guidance, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CTLA4 inhibitory signaling, organism-specific biosystem;
Function: hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; protein binding; protein tyrosine phosphatase activity;

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