"PTPN11" Related Products

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Recombinant Human PTPN11 (Active), GST-tagged

Cat.No. : PTPN11-1518H
Product Overview : Recombinant human PTPN11 (246-593) was expressed in E.coli cells using a N-terminal GST tag.
Description : Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 20 mM MOPS, pH 7.5, 50 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 30% glycerol.
Bio-activity : 597 nmol/min/mg
Molecular Mass : ~69 kDa
Protein length : 246-593 aa
Purity : >90%
Applications : Phosphatase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : PTPN11 protein tyrosine phosphatase, non-receptor type 11 [ Homo sapiens ]
Official Symbol : PTPN11
Synonyms : PTPN11; protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433;
Gene ID : 5781
mRNA Refseq : NM_002834
Protein Refseq : NP_002825
MIM : 176876
UniProt ID : Q06124
Chromosome Location : 12q24.1
Pathway : Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Axon guidance, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CTLA4 inhibitory signaling, organism-specific biosystem;
Function : hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; protein binding; protein tyrosine phosphatase activity;

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