"PTPN6" Related Products

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Recombinant Human PTPN6 (Active), GST-tagged

Cat.No.: PTPN6-1520H
Product Overview: Recombinant full length human PTPN6 was expressed in E.coli cells using an N-terminal GST tag.
Description: PTPN6 gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity. The PTPN6 was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway.
Source: E. coli
Species: Human
Tag: GST
Form: Recombinant protein stored in 20 mM MOPS, pH 7.5, 50 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 30% glycerol.
Bio-activity: 965 nmol/min/mg
Molecular Mass: ~93 kDa
Protein length: Full length
Purity: >90%
Applications: Phosphatase Assay, Western Blot
Storage: Store at–70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: PTPN6 protein tyrosine phosphatase, non-receptor type 6 [ Homo sapiens ]
Official Symbol: PTPN6
Synonyms: PTPN6; protein tyrosine phosphatase, non-receptor type 6; tyrosine-protein phosphatase non-receptor type 6; HCP; HCPH; PTP 1C; SHP 1; SHP1; hematopoietic cell phosphatase; protein-tyrosine phosphatase 1C; protein-tyrosine phosphatase SHP-1; hematopoietic cell protein-tyrosine phosphatase; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1;
Gene ID: 5777
mRNA Refseq: NM_002831
Protein Refseq: NP_002822
MIM: 176883
UniProt ID: P29350
Chromosome Location: 12p13.31
Pathway: Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem;
Function: hydrolase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity;

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