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Active Recombinant Human PTPRE, GST-tagged

Cat.No. : PTPRE-1523H
Product Overview : Recombinant human PTPRE (75-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Description : PTPRE or protein tyrosine phosphatase receptor type E is a member of the protein tyrosine phosphatase (PTP) family. This family of proteins are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRE is highly expressed in brain and testis. The regulatory roles of this PTP in Ras related signal transduction pathways, cytokines induced signaling, as well as the activation of voltage-gated K+ channels have been identified. PTPRE has a transmembrane segment and a cytoplasmic region containing duplicated PTPase domains.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 8,600 nmol/min/mg
Molecular Mass : ~91 kDa
Protein length : 75 aa-end
Purity : >95%
Applications : Phosphatase Assay, Western Blot
Storage : Store at–70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : PTPRE protein tyrosine phosphatase, receptor type, E [ Homo sapiens ]
Official Symbol : PTPRE
Synonyms : PTPRE; protein tyrosine phosphatase, receptor type, E; receptor-type tyrosine-protein phosphatase epsilon; PTPE; protein tyrosine phosphatase, receptor type, epsilon polypeptide; HPTPE; FLJ57799; FLJ58245; R-PTP-EPSILON; DKFZp313F1310;
Gene ID : 5791
mRNA Refseq : NM_006504
Protein Refseq : NP_006495
MIM : 600926
UniProt ID : P23469
Chromosome Location : 10q26
Function : hydrolase activity; protein binding; protein homodimerization activity; protein tyrosine phosphatase activity; receptor activity; transmembrane receptor protein tyrosine phosphatase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does PTPRE protein regulate cell signaling pathways? 01/10/2023

PTPRE protein acts as a phosphatase, dephosphorylating specific substrates involved in cell signaling, thereby modulating various cellular processes.

What types of cancer have shown a significant association with PTPRE protein dysregulation? 08/25/2022

Breast cancer, colorectal cancer, and prostate cancer are among the malignancies in which PTPRE protein dysregulation has been implicated.

How does PTPRE protein function in the nervous system? 02/21/2019

PTPRE protein plays a role in synaptic plasticity and neuronal development, and its dysregulation has been implicated in neurodegenerative diseases.

Can PTPRE protein inhibitors have potential side effects in clinical treatment? 11/16/2016

While PTPRE inhibitors may have off-target effects, research is focused on developing selective inhibitors to minimize potential adverse effects.

Are there any clinical trials targeting PTPRE protein in cancer treatment? 09/01/2016

Clinical trials evaluating the efficacy of PTPRE inhibitors in cancer therapy are currently underway, with promising early results.

Customer Reviews (3)

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Reviews
01/26/2021

    Whether utilized in protein-protein interaction studies or enzymatic assays, this protein exhibits robust performance, enabling accurate data generation and analysis.

    05/21/2020

      the PTPRE protein has demonstrated its efficacy in protein electron microscopy structure analysis.

      03/11/2018

        This cutting-edge technique allows for the visualization and characterization of protein structures at the atomic level, providing insights into their function and potential therapeutic targets.

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