"PTPRF" Related Products

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Recombinant Human PTPRF (Active), GST-tagged

Cat.No.: PTPRF-1524H
Product Overview: Recombinant human PTPRF (1275-1897) was expressed in E. coli cells using an N-terminal GST tag.
Description: PTPRF or LAR is a member of the protein tyrosine phosphatase family with an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. PTPRF has been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance.
Source: E. coli
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 454 nmol/min/mg
Molecular Mass: ~93 kDa
Protein length: 1275-1897 aa
Purity: >90%
Applications: Phosphatase Assay, Western Blot
Storage: Store at–70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: PTPRF protein tyrosine phosphatase, receptor type, F [ Homo sapiens ]
Official Symbol: PTPRF
Synonyms: PTPRF; protein tyrosine phosphatase, receptor type, F; LAR; receptor-type tyrosine-protein phosphatase F; LCA-homolog; leukocyte common antigen related; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; receptor-linked protein-tyrosine phosphatase LAR; protein tyrosine phosphatase, receptor type, F polypeptide; FLJ43335; FLJ45062; FLJ45567;
Gene ID: 5792
mRNA Refseq: NM_002840
Protein Refseq: NP_002831
MIM: 179590
UniProt ID: P10586
Chromosome Location: 1p34
Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Insulin Signaling, organism-specific biosystem; Insulin signaling pathway, organism-specific biosystem; Insulin signaling pathway, conserved biosystem;
Function: hydrolase activity; insulin receptor binding; phosphate ion binding; protein tyrosine phosphatase activity; receptor activity; receptor tyrosine kinase binding; transmembrane receptor protein tyrosine phosphatase activity;

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