Recombinant Human p18INK4C, GST-tagged

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Recombinant Human p18INK4C, GST-tagged

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Cat.No. : Cdkn2c-6983H
Product Overview : Recombinant full-length human p18INK4C was expressed in E. coli cells using an N-terminal GST tag.
Description : p18INK4C is a member of the INK4 family of proteins that regulate the G1 to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclin-dependent kinases 4 and 6. Mutation of p18INK4C impairs B-cell terminal differentiation and confers increased susceptibility to tumor development. p18INK4C can function as a tumor suppressor gene in Hodgkins lymphoma and its inactivation may contribute to the cell cycle deregulation and defective terminal differentiation characteristic of the Reed-Sternberg cells.
Source : E. coli
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass : ~42 kDa
Protein length : Full length
Purity : >90%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.2 μg/μl
Gene Name : CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) [ Homo sapiens ]
Official Symbol : Cdkn2c
Synonyms : CDKN2C; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); cyclin-dependent kinase 4 inhibitor C; INK4C; p18; p18-INK6; CDK6 inhibitor p18; cyclin-dependent inhibitor; cyclin-dependent kinase 6 inhibitor p18; p18-INK4C;
Gene ID : 1031
mRNA Refseq : NM_001262
Protein Refseq : NP_001253
MIM : 603369
UniProt ID : P42773
Chromosome Location : 1p32.3
Pathway : Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Cyclin D associated events in G1, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; G1 Phase, organism-specific biosystem;
Function : cyclin-dependent protein kinase inhibitor activity; protein kinase binding;

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