Recombinant Human CRKL, His-tagged
Cat.No. : | CRKL-6997H |
Product Overview : | Recombinant full length human CRKL was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. |
- Specification
- Gene Information
- Related Products
Description : | CRKL or v-crk sarcoma virus CT10 oncogene homolog (avian)-like is a protein kinase containing SH2 and SH3 (src homology) domains that activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase which plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic. CRKL is also required for normal cellular responses to Fgf8, including survival and migration, Erk activation, and target gene expression. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | His |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~39kDa |
Protein length : | Full length |
Purity : | >80% |
Applications : | Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.2μg/μl |
Gene Name : | CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like [ Homo sapiens ] |
Official Symbol : | CRKL |
Synonyms : | CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v crk avian sarcoma virus CT10 oncogene homolog like; crk-like protein; |
Gene ID : | 1399 |
mRNA Refseq : | NM_005207 |
Protein Refseq : | NP_005198 |
MIM : | 602007 |
UniProt ID : | P46109 |
Chromosome Location : | 22q11.21 |
Pathway : | B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem; |
Function : | SH3/SH2 adaptor activity; protein binding; signal transducer activity; |
Products Types
◆ Recombinant Protein | ||
CRKL-2736H | Recombinant Human CRKL Protein, His (Fc)-Avi-tagged | +Inquiry |
CRKL-1889H | Recombinant Human CRKL Protein, GST-tagged | +Inquiry |
CRKL-856R | Recombinant Rhesus Macaque CRKL Protein, His (Fc)-Avi-tagged | +Inquiry |
CRKL-0645H | Recombinant Human CRKL Protein (M1-E303), His/Strep tagged | +Inquiry |
CRKL-1261R | Recombinant Rat CRKL Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CRKL-403HCL | Recombinant Human CRKL cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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