"CDKL5" Related Products


Recombinant Human STK9, GST-tagged

Cat.No.: CDKL5-7022H
Product Overview: Recombinant human STK9 (CDKL5) (1-498) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: STK9 or CDKL5 is a member of Ser/Thr protein kinase family which has protein kinase activity and is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). STK9 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing, by controlling splicing factor dynamics. The mutations in the STK9 is a major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder.
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass: ~84 kDa
Protein length: 1-498 aa
Purity: >90%
Applications: Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1 μg/μl
Gene Name: CDKL5 cyclin-dependent kinase-like 5 [ Homo sapiens ]
Official Symbol: CDKL5
Synonyms: CDKL5; cyclin-dependent kinase-like 5; serine/threonine kinase 9 , STK9; EIEE2; serine/threonine kinase 9; serine/threonine-protein kinase 9; cyclin dependent kinase 5 transcript; ISSX; STK9;
Gene ID: 6792
mRNA Refseq: NM_003159
Protein Refseq: NP_003150
MIM: 300203
UniProt ID: O76039
Chromosome Location: Xp22
Function: ATP binding; Rac GTPase binding; cyclin-dependent protein kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity;

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