"NAGLU" Related Products

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Recombinant Human NAGLU, His-tagged

Cat. No.: NAGLU-1901H
Product Overview: Recombinant Human NAGLU(Met1­Trp743)fused with 6-his tag at C-terminal was expressed in CHO Cells.
Description: Human lysosomal α­N­acetylglucosaminidase is a hydrolase that catalyses the removal of terminal α­N­acetylglucosamine residues from heparan sulfate and heparin. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS­IIIB), also known as Sanfilippo syndrome B. Mucopolysaccharidosis types IIIA, C, and D are caused by mutations in other genes involved in the lysosomal degradation of heparan sulfate. Continuous lysosomal accumulation of heparan sulfate results in the clinical o combinant Human NAGLU(Met1­Trp743)fussed with 6-his tag at C-terminal was expressed in CHO Cells.nset of disease, which is typified by severe central nervous system degeneration. Mucopolysaccharidosis type III differs from other mucopolysaccharidoses in that patients usually exhibit mild somatic changes with minimal skeletal abnormalities.
Source: CHO Cells
Molecular Mass: The recombinant human NAGLU predicts a molecular mass of 81 kDa. It migrates as 70-95 kDa band in SDS-PAGE under reducing conditions.
N-terminal Sequence: Asp24
Formulation: Supplied as a 0.2 μm filtered solution in Tris and NaCl.
Purity: >95%, by SDS­PAGE
Bio-Activity: Measured by its ability to hydrolyze 4­Nitrophenyl­N­acetyl­α­D­glucosaminide. The specific activity is >900 pmol/min/μg, as measured under the decribed conditions.
Endotoxin Level: <1.0 EU per 1 μg of the protein by the LAL method.
Shipping: The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability &Storage: Use a manual defrost freezer and avoid repeated freezethaw cycles. 6 months from date of receipt, -20 to -70°C as supplied. 3 months, -20 to -70°C under sterile conditions after opening.
OfficialSymbol: NAGLU
Gene Name: NAGLU N-acetylglucosaminidase, alpha [ Homo sapiens ]
Synonyms: NAGLU; N-acetylglucosaminidase, alpha; NAG; MPS3B; UFHSD; MPS-IIIB; alpha-N-acetylglucosaminidase; N-acetyl-alpha-glucosaminidase; EC 3.2.1.50; UFHSD1; Alpha-N-acetylglucosaminidase 77 kDa form; alpha N acetylglucosaminidase, lysosomal; ANAG_HUMAN; ANAG
Gene ID: 4669
mRNA Refseq: NM_000263
Protein Refseq: NP_000254
MIM: 609701
UniProt ID: P54802
Chromosome Location: 17q21
Pathway: Glycosaminoglycan degradation; HS-GAG degradation; Heparan sulfate degradation; Heparan sulfate/heparin (HS-GAG) metabolism; Lysosome; Metabolism; Metabolism of carbohydrates
Function: alpha-N-acetylglucosaminidase activity

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