Recombinant Human AICDA, His-tagged AICDA-7113H

Recombinant Human AICDA, His-tagged

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Recombinant Human AICDA, His-tagged

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Cat.No. : AICDA-7113H
Product Overview : Recombinant human AICDA protein, fused to His-tag at N-terminus, was expressed in E.coli.
Description : AICDA, also known as AID, is involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. This protein is required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. It may also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Molecular Mass : 26.1kDa (218aa)
Protein length : 1-198aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MDSLLMNRRK FLYQFKNVRW AKGRRETYLC YVVKRRDSAT SFSLDFGYLR NKNGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG NPNLSLRIFT ARLYFCEDRK AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT FVENHERTFK AWEGLHENSV RLSRQLRRIL LPLYEVDDLR DAFRTLGL
Purity : >85% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/ml
Gene Name : AICDA activation-induced cytidine deaminase [ Homo sapiens ]
Official Symbol : AICDA
Synonyms : AICDA; activation-induced cytidine deaminase; AID; ARP2; CDA2; HIGM2; cytidine aminohydrolase; integrated into Burkitts lymphoma cell line Ramos;
Gene ID : 57379
mRNA Refseq : NM_020661
Protein Refseq : NP_065712
MIM : 605257
UniProt ID : Q9GZX7
Chromosome Location : 12p13
Pathway : IL4-mediated signaling events, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Primary immunodeficiency, organism-specific biosystem; Primary immunodeficiency, conserved biosystem; salvage pathways of pyrimidine deoxyribonucleotides, organism-specific biosystem; salvage pathways of pyrimidine ribonucleotides, organism-specific biosystem;
Function : cytidine deaminase activity; cytidine deaminase activity; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; metal ion binding; protein binding; zinc ion binding;

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