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Recombinant Human AICDA protein

Cat.No. : AICDA-1565H
Product Overview : Codon optimized AICDA gene to enhance the expression in E. coli. Amino Acid sequence remains the same as original gene. The protein is purified from E. coli and is biochemically active.
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Description : AID is the activation-induced cytidine deaminase. This small protein is required for somatic hypermutation during immunoglobulin development. It has been speculated that AID may be involved in deamination of cytosine residues in immunoglobulin gene. Its precise biochemical activity in somatic hypermutation, however, remains unknown.
Source : E. coli
Species : Human
Form : 50 mM TrisHCl (pH7.5), 800 mM NaCl, and 10% glycerol.
Molecular Mass : 24 kDa
AA Sequence : MDSLLMNRRKFLYQFKNVRWAKGRR ETYLCYVVKRRDSATSFSLDFGYLR NKNGCHVELLFLRYISDWDLDPGRC YRVTWFTSWSPCYDCARHVADFLRG NPNLSLRIFTARLYFCEDRKAEPEG LRRLHRAGVQIAIMTFKDYFYCWNT FVENHERTFKAWEGLHENSVRLSRQ LRRILLPLYEVDDLRDAFRTLGL
Storage : Stable for 2 years at -70 centigrade from date of shipment. Please aliquot to avoid repeated freezing and thawing.
Gene Name : AICDA activation-induced cytidine deaminase [ Homo sapiens ]
Official Symbol : AICDA
Synonyms : AICDA; activation-induced cytidine deaminase; AID; ARP2; CDA2; HIGM2; cytidine aminohydrolase; integrated into Burkitts lymphoma cell line Ramos;
Gene ID : 57379
mRNA Refseq : NM_020661
Protein Refseq : NP_065712
MIM : 605257
UniProt ID : Q9GZX7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (13)

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How is AICDA protein involved in antibody diversity? 10/30/2022

AICDA introduces mutations into the variable regions of immunoglobulin genes that code for the antigen-binding site, leading to the production of various forms of antibodies. These diverse antibodies can recognize different epitopes of pathogenic antigens and improve the immune system's ability to neutralize them.

What future directions of research on AICDA are being explored? 10/06/2022

Current studies are aimed at further understanding AICDA’s involvement in various immune-related diseases, as well as the mechanisms regulating its activity, like the post-transcriptional regulation of AICDA by microRNAs. Additionally, researchers are investigating the potential therapeutic benefits of targeting AICDA in different disease conditions.

Can AICDA be a potential therapeutic target for immunodeficiency and cancer treatments? 07/23/2022

AICDA inhibition has been proposed as a potential therapy for autoimmune diseases and some autoimmune-like disorders, where reduction of autoantibodies can alleviate the symptoms. AICDA inhibition could also be a promising strategy in the treatment of certain types of B-cell lymphomas and leukemias, where oncogenic hypermutation of immunoglobulin genes is a crucial driver of tumor development.

What disorders are associated with AICDA mutations? 12/27/2021

AICDA mutations have been linked to several immunodeficiency diseases, such as hyper-IgM syndrome type 2, which is a rare genetic disorder characterized by a deficiency in immunoglobulin G, A, and E, and impaired production of antibodies. AICDA mutations have also been found in patients with common variable immunodeficiency, a group of disorders where patients have low levels of immunoglobulin and decreased ability to fight infections.

How does AICDA-mediated class-switching contribute to immunity? 03/13/2021

AICDA-mediated class-switching is a process by which B cells change the type of antibody they produce from IgM to other antibody isotypes, such as IgG, IgA, and IgE. This process expands the repertoire of antibodies and increases the diversity of effector functions that can be elicited during an immune response. Class-switching is crucial for the clearance of different types of pathogens and is also important for the maintenance of immune homeostasis.

How is AICDA involved in the formation of lymphomas and leukemias? 10/25/2019

AICDA-mediated somatic hypermutation can introduce mutations in oncogenes or tumor suppressor genes that promote uncontrolled cell proliferation and contribute to the development of lymphomas and leukemias. Moreover, AICDA activity has been shown to increase the risk of chromosomal translocations that lead to the formation of abnormal fusion proteins that promote malignant transformation.

Are there any drugs that target AICDA? 12/23/2018

No drugs that specifically target AICDA have been approved for clinical use yet. However, several AICDA inhibitors have been proposed and tested in preclinical studies, including small molecules that inhibit AICDA activity, or agents that interfere with AICDA-mediated DNA damage response.

What are the diseases associated with AICDA mutations? 06/03/2017

Mutations in the AICDA gene have been linked to hyper-IgM immunodeficiency syndrome type 2, which is characterized by recurrent infections due to decreased levels of immunoglobulin. Moreover, AICDA mutations have also been linked to a higher incidence of B-cell lymphomas.

How is AICDA protein regulated? 06/02/2017

The expression of AICDA protein is regulated by various factors, including the activation of B cells by antigens, cytokines, and other immune cell signaling molecules. In addition, epigenetic factors, such as DNA methylation, histone modifications, and non-coding RNAs, can also regulate AICDA expression.

Does AICDA play a role in germinal center formation? 01/14/2017

germinal center formation? Yes, AICDA is a crucial mediator of germinal center formation and function. Germinal centers are specialized sites within lymphoid organs where B cells undergo somatic hypermutation and class-switch recombination to produce high-affinity antibodies. AICDA is expressed by activated B cells within germinal centers and is responsible for the vast majority of somatic hypermutation.

How is AICDA related to the development of autoimmunity? 08/18/2016

AICDA-mediated somatic hypermutation is essential for the production of high-affinity antibodies against pathogens. However, it can also lead to the generation of autoantibodies that recognize and attack host tissues, contributing to the development of autoimmune diseases. AICDA is involved in the breakdown of self-tolerance and the activation of autoreactive B cells.

What are the inhibitors of AICDA protein? 11/29/2015

AICDA protein inhibitors have been developed for inhibiting the activity of AICDA protein. Some of the inhibitors include caffeine, quercetin, and theophylline.

Are there any nonimmune functions of AICDA? 01/11/2015

Although AICDA is best known for its role in the immune system, recent studies have identified additional functions of AICDA in nonimmune cells. AICDA has been found to be involved in DNA demethylation, regulation of gene expression, and even lipid metabolism. AICDA expression has been observed in various nonimmune tissues, including the liver, brain, and adipose tissue, where it may have broader roles beyond its canonical function in antibody diversification.

Customer Reviews (5)

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Reviews
09/27/2020

    Its purity and functionality guarantee reliable and accurate results, ensuring the success of my research.

    03/28/2020

      the superior quality of the AICDA protein, combined with the outstanding technical support from its manufacturer, instills confidence in its efficacy and suitability for my experimental needs.

      07/19/2018

        the manufacturer of the AICDA protein provides exceptional technical support, making them an ideal partner in solving any challenges I may encounter during my experiments.

        03/25/2016

          The AICDA protein is characterized by its impeccable quality, making it a perfect choice to fulfill my experimental requirements.

          02/01/2016

            Their knowledgeable and responsive team is always ready to offer expert guidance, troubleshoot issues, and provide personalized solutions, ensuring a seamless research experience.

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