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Recombinant Human TDP1, His-tagged

Cat.No. : TDP1-7250H
Product Overview : Recombinant human TDP1, fused to His-tag at N-terminus, was expressed in E.coli.
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  • Gene Information
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Description : Tyrosyl-DNA phosphodiesterase 1, also known as TDP1, is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol.
Molecular Mass : 35.8 kDa
Protein length : 318aa
Purity : > 90% by SDS - PAGE.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay).
Gene Name : TDP1 tyrosyl-DNA phosphodiesterase 1 [ Homo sapiens ]
Official Symbol : TDP1
Synonyms : TDP1; tyrosyl-DNA phosphodiesterase 1; FLJ11090; SCAN1; tyr-DNA phosphodiesterase 1; MGC104252;
Gene ID : 55775
mRNA Refseq : NM_001008744
Protein Refseq : NP_001008744
MIM : 607198
UniProt ID : Q9NUW8
Chromosome Location : 14q32.11
Pathway : DNA Repair, organism-specific biosystem; Double-Strand Break Repair, organism-specific biosystem; Nonhomologous End-joining (NHEJ), organism-specific biosystem; Processing of DNA ends prior to end rejoining, organism-specific biosystem;
Function : 3-tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding; exonuclease activity; hydrolase activity; phosphoric diester hydrolase activity; protein binding; single-stranded DNA binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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