"TDP1" Related Products

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Recombinant Human TDP1, His-tagged

Cat.No.: TDP1-7250H
Product Overview: Recombinant human TDP1, fused to His-tag at N-terminus, was expressed in E.coli.
Description: Tyrosyl-DNA phosphodiesterase 1, also known as TDP1, is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol.
Molecular Mass: 35.8 kDa
Protein length: 318aa
Purity: > 90% by SDS - PAGE.
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml (determined by Bradford assay).
Gene Name: TDP1 tyrosyl-DNA phosphodiesterase 1 [ Homo sapiens ]
Official Symbol: TDP1
Synonyms: TDP1; tyrosyl-DNA phosphodiesterase 1; FLJ11090; SCAN1; tyr-DNA phosphodiesterase 1; MGC104252;
Gene ID: 55775
mRNA Refseq: NM_001008744
Protein Refseq: NP_001008744
MIM: 607198
UniProt ID: Q9NUW8
Chromosome Location: 14q32.11
Pathway: DNA Repair, organism-specific biosystem; Double-Strand Break Repair, organism-specific biosystem; Nonhomologous End-joining (NHEJ), organism-specific biosystem; Processing of DNA ends prior to end rejoining, organism-specific biosystem;
Function: 3-tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding; exonuclease activity; hydrolase activity; phosphoric diester hydrolase activity; protein binding; single-stranded DNA binding;

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