"POLR2J2" Related Products

Recombinant Human POLR2J2, His-tagged

Cat.No.: POLR2J2-7252H
product overview: Recombinant human POLR2J2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
description: POLR2J2 is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3" end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo.
source: E. coli
species: Human
tag: His
form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT, 250mM Imidazole
molecular mass: 15.5 kDa (138aa)
protein length: 1-115aa
aa sequence: MGSSHHHHHH SSGLVPRGSH MGSMNAPPAF ESFLLFEGEK ITINKDTKVP KACLFTINKE DHTLGNIIKS QLLKDPQVLF AGYKVPHPLEHKIIIRVQTT PDYSPQEAFT NAITDLISEL SLLEERFRTC LLPLRLLP
purity: >95% by SDS - PAGE
applications: SDS-PAGE
storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
concentration: 0.25 mg/ml
gene name: POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 [ Homo sapiens ]
official symbol: POLR2J2
synonyms: POLR2J2; polymerase (RNA) II (DNA directed) polypeptide J2; DNA-directed RNA polymerase II subunit RPB11-b1; RPB11b1; RNA polymerase II subunit B11-b1; DNA-directed RNA polymerase II subunit J2; DNA directed RNA polymerase II polypeptide J-related; HRPB11B; MGC54043; MGC105050;
Gene ID: 246721
mrna refseq: NM_032959
protein refseq: NP_116581
mim: 609881
uniprot id: Q9GZM3
chromosome location: 7q22.1
pathway: Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem; Metabolic pathways, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Pyrimidine metabolism, organism-specific biosystem; Pyrimidine metabolism, conserved biosystem;
function: DNA binding; DNA-directed RNA polymerase activity;

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