"ELANE" Related Products

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Human Elastase

Cat. No.: ELANE-1653H
Product Overview: Human ELANE having a molecular mass of 29.5kDa was purified from Human Neutrophil.
Description: ELANE, like trypsin and chymotrypsin, is a serine protease that also hydrolyses amides and esters. It is produced in the pancreas as an inactive zymogen, proelastase, and activated in the duodenum by trypsin. ELANE is distinctive in that it acts upon elastin.This enzyme degrades elastin, collagen, and proteoglycan and has been implicated in the development of pulmonary emphesema and rheumatoid arthritis.
Biological Activity: 20-22 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one micromole of Meo-Suc-Ala-Pro-Val-pNA per minute at 25°C in 100 mMTris-HCl, pH 7.5, with 500 mMNaCl.
Molecular Weight: 29.5 kDa
Form: Salt- free lyophilized solid
Appearance: Lyophilized protein
Reconstitution: Deionized water
Purity: ≥95% by SDS-PAGE
Storage: -20°C
Pathways: C-MYB transcription factor network; Systemic lupus erythematosus; amb2 Integrin signaling
Gene Name: ELANE elastase, neutrophil expressed [ Homo sapiens ]
Official Symbol: ELANE
Synonyms: ELANE; elastase, neutrophil expressed; GE; NE; HLE; HNE; ELA2; SCN1; PMN-E ; neutrophil elastase ; elastase-2; medullasin; PMN elastase; leukocyte elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclearelastase; bone marrow serine protease; granulocyte-derived elastase; elastase, neutrophil expressed; Bone marrow serine protease; Human leukocyte elastase; PMN elastase; granulocyte-derived elastase; EC 3.4.21.37; Elastase-2; Medullasin; EC 3.4.21
Gene ID: 1991
mRNA Refseq: NM_001972
Protein Refseq: NP_001963
MIM: 130130
UniProt ID: P08246
Chromosome Location: 19p13.3
Function: bacterial cell surface binding; cytokine binding; endopeptidase activity; heparin binding; peptidase activity; protein binding; serine-type endopeptidase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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