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Human Elastase

Cat.No. : ELANE-1653H
Product Overview : Human ELANE having a molecular mass of 29.5kDa was purified from Human Neutrophil.
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  • Gene Information
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Cat. No. : ELANE-1653H
Description : ELANE, like trypsin and chymotrypsin, is a serine protease that also hydrolyses amides and esters. It is produced in the pancreas as an inactive zymogen, proelastase, and activated in the duodenum by trypsin. ELANE is distinctive in that it acts upon elastin.This enzyme degrades elastin, collagen, and proteoglycan and has been implicated in the development of pulmonary emphesema and rheumatoid arthritis.
Biological Activity : 20-22 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one micromole of Meo-Suc-Ala-Pro-Val-pNA per minute at 25°C in 100 mMTris-HCl, pH 7.5, with 500 mMNaCl.
Molecular Weight : 29.5 kDa
Form : Salt- free lyophilized solid
Appearance : Lyophilized protein
Reconstitution : Deionized water
Purity : ≥95% by SDS-PAGE
Storage : -20°C
Pathways : C-MYB transcription factor network; Systemic lupus erythematosus; amb2 Integrin signaling
Gene Name : ELANE elastase, neutrophil expressed [ Homo sapiens ]
Official Symbol : ELANE
Synonyms : ELANE; elastase, neutrophil expressed; GE; NE; HLE; HNE; ELA2; SCN1; PMN-E ; neutrophil elastase ; elastase-2; medullasin; PMN elastase; leukocyte elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclearelastase; bone marrow serine protease; granulocyte-derived elastase; elastase, neutrophil expressed; Bone marrow serine protease; Human leukocyte elastase; PMN elastase; granulocyte-derived elastase; EC 3.4.21.37; Elastase-2; Medullasin; EC 3.4.21
Gene ID : 1991
mRNA Refseq : NM_001972
Protein Refseq : NP_001963
MIM : 130130
UniProt ID : P08246
Chromosome Location : 19p13.3
Function : bacterial cell surface binding; cytokine binding; endopeptidase activity; heparin binding; peptidase activity; protein binding; serine-type endopeptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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06/17/2019

    In terms of performance, it delivers unwavering reliability, meeting the demands of even the most complex experiments.

    07/30/2018

      Stringent quality control measures ensure consistent quality across every batch of the reagent.

      04/29/2016

        Minimal quantities are required, offering cost-saving benefits for both sample and reagent consumption.

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