Recombinant Human Adenosine Kinase, His-tagged

Cat. No.: ADK-2481H
Product Overview: Recombinant human Adenosine kinase, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 40.5 kDa (362aa).
Description: Adenosine kinase, also known as ADK is an abundant enzyme in mammalian tissues that catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine kinase has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents.
Source: E.coli.
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 1mM EDTA, 50mM NaCl.
Purity: > 95% by SDS – PAGE.
Concentration: 0.5 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MRENILFGMG NPLLDISAVV DKDFLDKYSL KPNDQILAED KHKELFDELV KKFKVEYHAG GSTQNSIKVA QWMIQQPHKA ATFFGCIGID KFGEILKRKA AEAHVDAHYY EQNEQPTGTC AACITGDNRS LIANLAAANC YKKEKHLDLE KNWMLVEKAR VCYIAGFFLT VSPESVLKVA HHASENNRIF TLNLSAPFIS QFYKESLMKV MPYVDILFGN ETEAATFARE QGFETKDIKE IAKKTQALPK MNSKRQRIVI FTQGRDDTIM ATESEVTAFA VLDQDQKEII DTNGAGDAFV GGFLSQLVSD KPLTECIRAG HYAASIIIRR TGCTFPEKPD FH.
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: ADK adenosine kinase [ Homo sapiens ]
Synonyms: adenosine kinase; AK; ADK; adenosine 5"-phosphotransferase;Adenosine 5"-phosphotransferase; EC 2.7.1.20
Gene ID: 132
mRNA Refseq: NM_001123
Protein Refseq: NP_001114
MIM: 102750
UniProt ID: P55263
Chromosome Location: 10q22; 10q11-q24
Pathway: Metabolic pathways; Purine metabolism; Metabolism of nucleotides
Function: ATP binding; adenosine kinase activity; kinase activity; metal ion binding; nucleotide binding; transferase activity

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