Recombinant Human QDPR, His-tagged

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Recombinant Human QDPR, His-tagged

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Cat. No. : QDPR-3613H
Product Overview : Recombinant human QDPR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Description : QDPR is a member of the short-chain dehydrogenases/reductase(SDR) family of enzymes. Functioning as a homodimer, QDPR plays an important role in the recycling of tetrahydrobiopterin (BH4), an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine). More specifically, QDPR catalyzes the regeneration of BH4 from quinonoid dihydrobiopterin (qBH2), the product generated from the hydroxylation reactions. Mutations in the gene encoding QDPR can lead to phenylketonuria II.
Form : Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT.
Molecular Weight : 28.2 kDa (267aa), confirmed by MALDI-TOF
Purity : > 90 % by SDS - PAGE
Concentration : 1 mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MGSMAAAAAA GEARRVLVYG GRGALGSRCV QAFRARNWWV ASVDVVENEE ASASIIVKMT DSFTEQADQV TAEVGKLLGE EKVDAILCVA GGWAGGNAKS KSLFKNCDLM WKQSIWTSTI SSHLATKHLK EGGLLTLAGA KAALDGTPGM IGYGMAKGAV HQLCQSLAGK NSGMPPGAAA IAVLPVTLDT PMNRKSMPEA DFSSWTPLEF LVETFHDWIT GKNRPSSGSL IQVVTTEGRT ELTPAYF
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Figure :

Gene Name : QDPR quinoid dihydropteridine reductase [ Homo sapiens ]http://www.ncbi.nlm.nih.gov/sites/entrez
Official Symbol : QDPR
Synonyms : QDPR; DHPR; PKU2; SDR33C1; FLJ42391; quinoid dihydropteridine reductase; dihydropteridine reductase; HDHPR;EC 1.5.1.34; OTTHUMP00000158671; OTTHUMP00000217799; OTTHUMP00000217800; OTTHUMP00000217802; OTTHUMP00000217914; OTTHUMP00000217915; 6,7-dihydropteridine reductase; short chain dehydrogenase/reductase family 33C, member 1
Gene ID : 5860
mRNA Refseq : NM_000320
Protein Refseq : NP_000311
MIM : 612676
UniProt ID : P09417
Chromosome Location : 4p15.31
Function : 6,7-dihydropteridine reductase activity; binding; electron carrier activity; oxidoreductase activity

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