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Recombinant Rat Pvrl1, His-tagged

Cat.No.: Pvrl1-7473R
Product Overview: A DNA sequence encoding the rat PVRL1(Met1-Ala354) was expressed in Human Cells, with a His tag at the C-terminus.
Description: Poliovirus receptor-related protein 1, also known as Herpes virus entry mediator C, Nectin-1, Herpesvirus Ig-like receptor, CD111, PVRL1 and HVEC, is a single-pass type I membrane protein which belongs to the nectin family. PVRL1 acts in the initiation and maintenance of epithelial adherens junctions. Both rare and common mutations within PVRL1 make a minor contribution to disrupting the initiation and regulation of cell-to-cell adhesion and downstream morphogenesis of the embryonic face. PVRL1 can form trans-heterodimers with PVRL3 / nectin-3 and with PVRL4 / nectin-4. PVRL1 interacts (via C-terminus) with afadin (via PDZ domain). This interaction recruits PVRL1 to cadherin-based adherens junctions. PVRL1 interacts with integrin alphaV / beta3. It also interacts with herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV) envelope glycoprotein D. PVRL1 functions as an entry receptor for these viruses. Defects in PVRL1 are the cause of ectodermal dysplasia Margarita Island type (EDMI), also known as Zlotogora-Ogur syndrome, cleft lip/palate-ectodermal dysplasia syndrome (CLPED1) or ectodermal dysplasia 4. Defects in PVRL1 are also the cause of non-syndromic orofacial cleft type 7 (OFC7). Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate.
Source: Human Cells
Species: Rat
Tag: His
Predicted N Terminal: Gln 31
Form: Lyophilized from a 0.2μM filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Molecular Mass: The recombinant rat PVRL1 comprises 335 amino acids and predicts a molecular mass of 37.6 kDa. The apparent molecular mass of the recombinant protein is approximately 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Endotoxin: 1.0 eu/μg of the protein as determined by the lal
Purity: >97 % as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name: Pvrl1 poliovirus receptor-related 1 [ Rattus norvegicus ]
Official Symbol: Pvrl1
Synonyms: PVRL1; poliovirus receptor-related 1; poliovirus receptor-related protein 1; nectin); poliovirus receptor-related 1 (herpesvirus entry mediator C; HveC; nectin-1;
Gene ID: 192183
Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Adherens junctions interactions, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem;
Function: carbohydrate binding; cell adhesion molecule binding; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor activity; virion binding;

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