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Native Cow TRIM21

Cat. No.: TRIM21-212B
Product Overview: Cow full length TRIM21 was purified from Bovine thymus tissue.
Description: A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B (''Thr-187'' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.
Source: Bovine thymus tissue
Molecular Mass: 54kDa
Formulation: Liquid
Purity: >90% as determined by SDS­PAGE
Storage buffer: Constituents: 20% Glycerol, 0.1% Micr-O-protect
Applications: ELISA; SDS-PAGE
Storage: Shipped on dry ice. Upon delivery aliquot and store at -20ºC. Avoid freeze / thaw cycles.
OfficialSymbol: TRIM21
Gene Name: TRIM21 tripartite motif containing 21 [ Bos taurus ]
Synonyms: E3 ubiquitin-protein ligase TRIM21; SS-A; ro(SS-A); 52 kDa Ro protein; 52kD Ro/SSA autoantigen; tripartite motif-containing 21; sjoegren syndrome type A antigen; tripartite motif-containing protein 21; 52 kDa ribonucleoprotein autoantigen Ro/SS-A
Gene ID: 359715
mRNA Refseq: NM_182655
Protein Refseq: NP_872596
UniProt ID: Q7YRV4
Chromosome Location: 15
Pathway: Systemic lupus erythematosus
Function: DNA binding; RNA binding; ubiquitin-protein ligase activity; zinc ion binding

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