Recombinant Mouse TNFSF11, Fc-tagged
Cat.No. : | Tnfsf11-198M |
Product Overview : | Recombinant Mouse TNFSF11 encoding the extracellular domain of mouse TNFSF11 (Arg 72-Asp 316), fused with the Fc region of human IgG1 at the N-terminus, was expressed in Human Cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | Tnfsf11-198M |
Description : | RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. |
Source : | Human Cells |
MolecularMass : | The recombinant mouse TNFSF11/Fc is a disulfide-linked homodimer. The reduced monomer comprises 505 amino acids and has a calculated molecular mass of 56 kDa. The apparent molecular mass of the monomer is approximately 50 kDa in SDS-PAGE under reducing conditions. |
PredictedN terminal : | Glu |
Formulation : | Lyophilized from 0.2μm filtered solution of PBS, pH7.4. |
Purity : | >87 % as determined by SDSPAGE. |
Endotoxin : | <1.0 EU per μg of the protein as determined by the LAL method |
Storage : | Store it under sterile conditions at -70 oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | Tnfsf11 |
Gene Name : | Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 [ Mus musculus ] |
Synonyms : | Tnfsf11; tumor necrosis factor (ligand) superfamily, member 11; ODF; OPG; OPGL; RANKL; Ly109l; Trance; OPG ligand; osteoprotegerin ligand; osteoclast differentiation factor; receptor activator of NF-kappaB ligand; tumor necrosis factor-related activation-induced cytokine; Ly109l |
Gene ID : | 21943 |
mRNA Refseq : | NM_011613 |
Protein Refseq : | NP_035743 |
UniProt ID : | O35235 |
Chromosome Location : | 14 D3 |
Pathway : | Cytokine-cytokine receptor interaction |
Function : | cytokine activity; protein binding; receptor activity; tumor necrosis factor receptor binding |
Products Types
◆ Recombinant Protein | ||
TNFSF11-210C | Active Recombinant Cynomolgus TNFSF11 protein(Gly136-Asp317), hFc-tagged | +Inquiry |
TNFSF11-0757H | Active Recombinant Human TNFSF11 protein(Gly64-Asp245), hFc-tagged | +Inquiry |
TNFSF11-2023M | Recombinant Mouse TNFSF11 Protein, His-tagged | +Inquiry |
TNFSF11-459H | Recombinant Human TNFSF11 Protein, His-tagged | +Inquiry |
TNFSF11-255M | Active Recombinant Mouse TNFSF11 Protein | +Inquiry |
◆ Lysates | ||
TNFSF11-001CCL | Recombinant Cynomolgus TNFSF11 cell lysate | +Inquiry |
TNFSF11-998HCL | Recombinant Human TNFSF11 cell lysate | +Inquiry |
TNFSF11-1586MCL | Recombinant Mouse TNFSF11 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIt is possible to detect the expression level of TNFSF11 protein to help diagnose tumors and other diseases, and to assess their prognosis and treatment effectiveness.
At present, a variety of drugs have been developed to target TNFSF11 proteins and their related signaling pathways, including inhibiting their expression and inhibiting their binding to receptors, etc., for the treatment of tumors and other bone metabolism-related diseases.
Studies have shown that TNFSF11 proteins can be involved in the regulation of infectious diseases, such as playing a role in some viral infections.
There are differences in the expression of TNFSF11 proteins in different tissues and organs, and they are expressed in tissues and organs such as the immune system, bones, and teeth, and the expression level may be affected by many factors.
Studies have shown that TNFSF11 proteins can be involved in the regulation of autoimmune diseases, such as in autoimmune diseases such as rheumatoid arthritis.
TNFSF11 protein belongs to the TNF superfamily and has certain structural and functional similarities with other members of the TNF superfamily.
Customer Reviews (3)
Write a reviewThe reproducibility of TNFSF11 is so good that the results are highly consistent regardless of the conditions under which the experiment or application is performed, greatly reducing the experimental error.
Green production process of TNFSF11 is highly commendable, which uses the most advanced biotechnology to increase production efficiency and reduce environmental impact.
The short half-life and high clearance of TNFSF11 make it better able to adapt to changing treatment needs and provide patients with more flexible treatment options.
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