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Recombinant Mouse TNFSF11, Fc-tagged

Cat. No.: Tnfsf11-198M
Product Overview: Recombinant Mouse TNFSF11 encoding the extracellular domain of mouse TNFSF11 (Arg 72-Asp 316), fused with the Fc region of human IgG1 at the N-terminus, was expressed in Human Cells.
Description: RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
Source: Human Cells
MolecularMass: The recombinant mouse TNFSF11/Fc is a disulfide-linked homodimer. The reduced monomer comprises 505 amino acids and has a calculated molecular mass of 56 kDa. The apparent molecular mass of the monomer is approximately 50 kDa in SDS-PAGE under reducing conditions.
PredictedN terminal: Glu
Formulation: Lyophilized from 0.2μm filtered solution of PBS, pH7.4.
Purity: >87 % as determined by SDS­PAGE.
Endotoxin: <1.0 EU per μg of the protein as determined by the LAL method
Storage: Store it under sterile conditions at -70 oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
OfficialSymbol: Tnfsf11
Gene Name: Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 [ Mus musculus ]
Synonyms: Tnfsf11; tumor necrosis factor (ligand) superfamily, member 11; ODF; OPG; OPGL; RANKL; Ly109l; Trance; OPG ligand; osteoprotegerin ligand; osteoclast differentiation factor; receptor activator of NF-kappaB ligand; tumor necrosis factor-related activation-induced cytokine; Ly109l
Gene ID: 21943
mRNA Refseq: NM_011613
Protein Refseq: NP_035743
UniProt ID: O35235
Chromosome Location: 14 D3
Pathway: Cytokine-cytokine receptor interaction
Function: cytokine activity; protein binding; receptor activity; tumor necrosis factor receptor binding

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