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Recombinant Human USP10, Flag-tagged

Cat.No. : USP10-391H
Product Overview : Recombinant Human USP10 fused with an N-terminal FLAG-tag, expressed in a baculovirus-infected Sf9 cell expression system.
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  • Gene Information
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Cat. No. : USP10-391H
Description : Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene.
Source : Baculovirus
Molecular Mass : 88 kDa
Formulation : 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 90 μg/ml Flag peptide, 10% glycerol, and 3 mM DTT.
Purity : ≥60%
Specific Activity : 23 pmol/min/μg. Assay conditions: Reaction was performed in 50 mM Tris, pH 7.4, 1 mM DTT, 0.5 mM EDTA, 500 nM Ub-AMC, and USP10 in a 50 μL reaction. Reaction was incubated at 37 °C for 15 min and fluorescent signal was measured at excitation 340 nm, emission 460 nm.
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : >6 months at –80 °C
OfficialSymbol : USP10
Gene Name : USP10 ubiquitin specific peptidase 10 [Homo sapiens]
Synonyms : ubiquitin specific peptidase 10; Ubiquitin-specific-processing protease 10; KIAA0190; MGC2621; UBPO; ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific protease 10; ubiquitin thioesterase 10; Deubiquitinating enzyme 10; EC 3.4.19.12; Ubiquitin thiolesterase 10
Gene ID : 9100
mRNA Refseq : NM_005153
Protein Refseq : NP_005144
MIM : 609818
UniProt ID : Q14694
Chromosome Location : 16q24.1
Pathway : cysteine-type peptidase activity; cystic fibrosis transmembrane conductance regulator binding; p53 binding; peptidase activity; protein binding; ubiquitin thiolesterase activity; ubiquitin-specific protease activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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