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Active Recombinant Human IGF2R, His-tagged

Cat.No. : IGF2R-677H
Product Overview : Recombinant Human IGF2R (Gln41­Asp1365) fused with a C­terminal 6­His tag, was expressed in CHO Cells.
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  • Gene Information
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Cat. No. : IGF2R-677H
Description : The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. While the mouse Igf2r gene shows exclusive expression from the maternal allele, imprinting of the human IGF2R gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.
Source : CHO Cells
Molecular Mass : The predicted molecular mass is 147 kDa (monomer). The apparent molecular mass of the monomer is approximately 160­180 kDa in SDS-PAGE under reducing conditions.
Predicted N terminal : Ala43
Formulation : Lyophilized from a 0.2 μm filtered solution in PBS.
Purity : >95% as determined by SDS­PAGE
Activity : Measured by its binding ability in a functional ELISA.When Recombinant Human IGF­IIR is immobilized at 2 μg/mL (100 µL/well),the concentration of Recombinant Human CREG that produces 50% of theoptimal binding response is found to be approximately 2 - 10 ng/mL.
EndotoxinLevel : <0.01 EU per 1 μg of the protein by the LAL method.
Storage : 12 months from date of receipt, ­20 to ­70 °C as supplied. Avoid repeated freeze­thaw cycles.
OfficialSymbol : IGF2R
Gene Name : IGF2R insulin-like growth factor 2 receptor [ Homo sapiens ]
Synonyms : IGF2R; insulin-like growth factor 2 receptor; cation-independent mannose-6-phosphate receptor; cation independent mannose 6 phosphate receptor; CD222; CIMPR; M6PR; MPR1; MPRI
Gene ID : 3482
mRNA Refseq : NM_000876
Protein Refseq : NP_000867
MIM : 147280
UniProt ID : P11717
Chromosome Location : 6q26
Pathway : Clathrin derived vesicle budding; Golgi Associated Vesicle Biogenesis; Lysosome; Membrane Trafficking
Function : glycoprotein binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; mannose binding; phosphoprotein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is there a link between IGF2R and diabetes? 11/28/2022

Yes, disruptions in IGF2R function have been associated with insulin resistance and diabetes. Understanding this link is vital for developing interventions in diabetes management.

Can IGF2R be used as a prognostic marker in certain diseases? 09/09/2021

In some diseases, altered levels of IGF2R may serve as a prognostic marker, providing insights into the progression and severity of the condition.

Are there ongoing clinical trials targeting IGF2R? 12/22/2020

Yes, several clinical trials are exploring the therapeutic potential of targeting IGF2R in various diseases, including cancer and metabolic disorders.

How does IGF2R interact with other signaling pathways in the body? 06/26/2020

IGF2R interacts with multiple signaling pathways, including the mTOR pathway, impacting cellular processes such as growth, metabolism, and autophagy.

How does IGF2R contribute to fetal development? 06/12/2019

During fetal development, IGF2R regulates the levels of IGF2, influencing fetal growth. Dysregulation can lead to developmental abnormalities.

Customer Reviews (3)

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Reviews
04/26/2023

    Its ability to modulate the activity of essential signaling pathways involved in these processes makes it a valuable tool for unraveling their complexities.

    11/16/2021

      the manufacturer's commitment to innovation and product development instills confidence in the reliability and future potential of the ARHGEF9B protein.

      10/26/2018

        Their technical expertise and prompt customer service have been instrumental in resolving any challenges or questions I encountered throughout my research journey.

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