"DVL3" Related Products


Goat Anti-Human DVL3 Polyclonal Antibody

Cat.No.: CPBT-Y0051RH
Product Overview: Goat Anti-Human DVL3 Polyclonal Antibody
Antigen Description: Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer's studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway.
Target: DVL3
Host: Goat
Isotype: IgG
Source: Dvl-3 is an affinity purified goat polyclonal antibody raised against apeptide mapping near the C-terminus of Dvl-3 of human origin
species: Human
Cross Reactivity: Mouse,Rat and Human
Applications: WB, IP, IF and ELISA
Storage: Store at 4° C, **DO NOT FREEZE**. Stable for one year from the date of shipment. Non-hazardous. No MSDS required.
Gene Name: DVL3 dishevelled, dsh homolog 3 (Drosophila) [ Homo sapiens ]
Official Symbol: DVL3
Synonyms: DVL3; dishevelled, dsh homolog 3 (Drosophila); dishevelled 3 (homologous to Drosophila dsh); segment polarity protein dishevelled homolog DVL-3; KIAA0208; DSH homolog 3; dishevelled-3;
Gene ID: 1857
mRNA Refseq: NM_004423
Protein Refseq: NP_004414
MIM: 601368
UniProt ID: Q92997
Chromosome Location: 3q27
Pathway: Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Canonical Wnt signaling pathway, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Melanogenesis, organism-specific biosystem;
Function: beta-catenin binding; frizzled binding; protease binding; protein binding; protein heterodimerization activity; receptor binding; signal transducer activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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