Goat Anti-Human DVL3 Polyclonal Antibody


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Goat Anti-Human DVL3 Polyclonal Antibody

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Cat.No. : CPBT-Y0051RH
Product Overview : Goat Anti-Human DVL3 Polyclonal Antibody
Antigen Description : Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer's studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway.
Target : DVL3
Host : Goat
Isotype : IgG
Source : Dvl-3 is an affinity purified goat polyclonal antibody raised against apeptide mapping near the C-terminus of Dvl-3 of human origin
species : Human
Cross Reactivity : Mouse,Rat and Human
Applications : WB, IP, IF and ELISA
Storage : Store at 4° C, **DO NOT FREEZE**. Stable for one year from the date of shipment. Non-hazardous. No MSDS required.
Gene Name : DVL3 dishevelled, dsh homolog 3 (Drosophila) [ Homo sapiens ]
Official Symbol : DVL3
Synonyms : DVL3; dishevelled, dsh homolog 3 (Drosophila); dishevelled 3 (homologous to Drosophila dsh); segment polarity protein dishevelled homolog DVL-3; KIAA0208; DSH homolog 3; dishevelled-3;
Gene ID : 1857
mRNA Refseq : NM_004423
Protein Refseq : NP_004414
MIM : 601368
UniProt ID : Q92997
Chromosome Location : 3q27
Pathway : Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Canonical Wnt signaling pathway, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Melanogenesis, organism-specific biosystem;
Function : beta-catenin binding; frizzled binding; protease binding; protein binding; protein heterodimerization activity; receptor binding; signal transducer activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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