Recombinant Human TDP2, His-tagged

• Cat.No.: TDP2-7580H
• Product Overview: Recombinant human TDP2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Antigen Description: TDP2 is a member of a superfamily of divalent cation-dependent phosphodiesterases. The protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
• Molecular Mass: 43.3 kDa (385aa) confirmed by MALDI-TOF
• Protein length: 1-362aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMELGSCL EGGREAAEEE GEPEVKKRRL LCVEFASVAS CDAAVAQCFL AENDWEMERA LNSYFEPPVE ESALERRPET ISEPKTYVDL TNEETTDSTT SKISPSEDTQ QENGSMFSLI TWNIDGLDLN NLSERARGVC SYLALYSPDV IFLQEVIPPY YSYLKKRSSN YEIITGHEEG YFTAIMLKKS RVKLKSQEII PFPSTKMMRN LLCVHVNVSG NELCLMTSHL ESTRGHAAER MNQLKMVLKK MQEAPESATV IFAGDTNLRD REVTRCGGLP NNIVDVWEFL GKPKHCQYTW DTQMNSNLGI TAACKLRFDR IFFRAAAEEG HIIPRSLDLL GLEKLDCGRF PSDHWGLLCN LDIIL
• Purity: >85% as determined by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: TDP2 tyrosyl-DNA phosphodiesterase 2 [ Homo sapiens ]
• Official Symbol: TDP2
• Synonyms: TDP2; tyrosyl-DNA phosphodiesterase 2; TRAF and TNF receptor associated protein , TTRAP; ETS1-associated protein 2; ETS1-associated protein II; tyr-DNA phosphodiesterase 2; 5-Tyr-DNA phosphodiesterase; 5-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor associated protein; TRAF and TNF receptor-associated protein; EAP2; AD022; EAPII; TTRAP; dJ30M3.3; RP1-30M3.3; MGC9099; MGC111021
• Gene ID: 51567
• mRNA Refseq: NM_016614
• Protein Refseq: NP_057698
• MIM: 605764
• UniProt ID: O95551
• Chromosome Location: 6p22.3-p22.1
• Pathway: CD40/CD40L signaling, organism-specific biosystem
• Function: 5-tyrosyl-DNA phosphodiesterase activity; hydrolase activity; magnesium ion binding; nuclease activity; protein binding; transcription corepressor activity